[Seminar] Guest Seminar on 03rd April, 3:00pm
office bio office
IIT BOMBAY
SEMINAR NOTICE
Speaker : Sanjay V. Malhotra, PhD; FRSC
Laboratory of Synthetic Chemistry- SAIC
National Cancer Institute, Frederick, MD 21702, USA
Topic :“Himalayan mayapple to anti-cancer therapeutics”
Day and
Date : Tuesday, 03rd April, 2012
Time : 3:00 PM
Venue : Seminar Room No. 402, 3rd floor
All are invited.
Prof. Samir Maji
(Seminar Secretary)
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ABSTRACT :
"Himalayan mayapple to anti-cancer therapeutics"
Sanjay V. Malhotra, PhD; FRSC
Laboratory of Synthetic Chemistry- SAIC
National Cancer Institute, Frederick, MD 21702, USA
The perennial herb Podophyllum hexandrum (syn. P. emodi), bearing the
common names Himalayan mayapple or Indian may apple, is native to the
lower elevations in and surrounding the Himalaya. Compounds
Podophyllotoxin (PPT) from these trees are one of the well-known naturally
occurring aryltetralin lignans, whose medicinal properties, such as
cathartic, antirheumatic, antiviral and antitumor activity, have been
well-recognized for centuries. But attempts to use PPT in the treatment of
human neoplasia were mostly unsuccessful due to the complicated side
effects such as nausea, vomiting, and damage of normal tissues, etc.
Therefore, PPT has been used as a lead compound for drug design to obtain
more potent and less toxic anticancer agents. Derivatives of
podophyllotoxin, namely etoposide, etopophos and teniposide have been
developed for the treatment of a variety of malignancies. However, due to
the drug resistance developed by cancer cells as well as side effects
associated with the use of these agents in clinic, the search for new
effective anticancer analogues of podophyllotoxin remains an intense area
of research. The talk will cover the current status and development in our
laboratories on aza-podophyllotoxin analogs for anticancer activity.
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