Hi Leah,
There were issues with IGV today that have been resolved. Can you try again, in case those issues were affecting you.
If it still doesn't work you can try reseting all preferences to the IGV defaults by renaming (or removing) the files prefs.properties in the igv folder in your user home. Do this while IGV is not running, and then restart IGV
If that doesn't help, can you send us the information from the log of the IGV run that fails. The log can be found in the igv.log file under the igv folder in your user home. Also let us know which version of IGV you are running (IGV version number, and also whether you are running the Mac App with or without Java, or the command line version).
Helga