I was trying to segment a 3D image stack (156x156x100, 2MB) using the active contours plugin but every time my computer froze half way.
Java(TM) SE Runtime Environment 1.8.0_51-b16 (64 bit)
Running on Windows 8.1 6.3 (amd64)
Number of processors : 16
System total memory : 31.9 GB
System available memory : 28.5 GB
Max java memory : 13.0 GB