So, it looks like there isn't a problem with Hyperspy or DM - it`s just that my files are too big!
I've attempted cropping one of my 1.3GB files to make it a bit smaller, and at 750 MB it opens without issue.
Are there any other ways of opening my files in DM than going through the Rpl route? (FYI - the file before denoising is bigger, and opens fine - there might be a case of the RPL file temporary using silly amounts of memory, but I haven't noticed it)
In short, I'm denoising the data in Hyperspy, then doing MLLS fitting using DM, which it does very quickly. This is why I'm using the Rpl file.
Again, thoughts on the matter are appreciated!
- Tom