Detecting high abundance of mammalian MetaCyc pathways

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Nick

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Dec 26, 2019, 3:32:03 AM12/26/19
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Hi, I've run Humann2 (using default settings and the chocophlan database) on human gut shotgun metagenomic samples that has been quality trimmed and dehosted (mapped against hg38) but I still find mammalian pathways with high abundance, eg.

COA-PWY-1: coenzyme A biosynthesis II (mammalian)
LYSINE-DEG1-PWY: L-lysine degradation XI (mammalian)
PWY-6309: L-tryptophan degradation XI (mammalian, via kynurenine)

I know that Humann2 is quite conservative, but is it possible these are false positives? Or is there some alternate explanation?
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