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TBL3 Bioenergetics
Why are some compounds classified as “high energy” compounds?
“High energy compounds” are compounds that have a high capacity to do work; thereby, they have a large negative ΔG0 value (between -5 to -15 kcal/mole). The products of hydrolysis are more stable than reactants for high energy compounds. Generally, molecules with shorter, multiple (i.e. double and triple bonds), and or phsophoanhydride bonds are considered high energy. An example of a high energy compounds is ATP. Some others are 1,3 Bisphosphoglycerate, phosphoenolpyruvate, and creatine phosphate.
Why are products of hydrolysis of high energy compounds more stable than reactants?
Products of hydrolysis of high energy compounds are more stable than the reactants because they are at a lower energy state. These products have a greater resonance stability; therefore there is less bond strain, due to electrostatic repulsion of oxygen atoms. During hydrolysis bonds are broken between oxygen and hydrogen, releasing energy and water.
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