I wish I could pinpoint this to whether or not it started with one of the latest updates, but I'm not certain...
What's happening is that with Fiddler capturing, IE 11 (on Windows 7) is getting 401 errors when trying to connect to a service being run as part of a web application. It just started happening in the past few days. If stop capturing, it starts working again.
Please let me know if there is more information that you need.
Thanks