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Onofre Alamillo

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Jul 8, 2024, 12:33:15 PM7/8/24
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Here's a quick roundup of stories you might have missed today.

Cynthia Erivo to Play Aretha Franklin in Third Season of Genius
Cynthia Erivo, the Tony-winning Color Purple breakout star who will soon embody Harriet Tubman in the upcoming biopic Harriet, has been cast as another icon, Aretha Franklin, in the third season of the National Geographic series Genius, according to The Hollywood Reporter. Erivo will portray the Queen of Soul throughout the season, titled Genius: Aretha, which is being billed as an authorized account of Franklin's life and music. Pulitzer-winning playwright Suzan-Lori Parks (Topdog/Underdog) will serve as showrunner. "Aretha Franklin has been a source of inspiration for me since I was a little girl," said Erivo. "Her strength, passion and soul are evident in her everlasting legacy, not only as a transcendent artist but as a humanitarian and civil rights icon."

Watch Lin-Manuel Miranda in the Official Trailer for His Dark Materials
The long-awaited first trailer is here for season one of HBO's miniseries adaptation of the bestselling His Dark Materials novels. Tony winner Lin-Manuel Miranda and Tony nominee Ruth Wilson appear in the new series, which is adapted by Tony winner Jack Thorne (Harry Potter and the Cursed Child), with the first two episodes directed by Oscar winner Tom Hooper (the upcoming Cats film). Dive in to the thrilling trailer below and mark your calendar: His Dark Materials debuts November 4 on HBO.



Mj Rodriguez, Jane Krakowski & More Join MCC Theater's Celebrity Game Night
A slew of stars have signed on for MCC Theater's upcoming fundraiser Let's Play! Celebrity Game Night, to be held on November 3 at 6:00pm at The Garage in midtown Manhattan. The evening's players will include Mj Rodriguez, Jane Krakowski, Cynthia Nixon, Katie Holmes, Alan Cumming, Michael Kelly, Samantha Mathis, Margo Martindale, Thomas Sadoski and Amanda Seyfried. As previously announced, hosts and team captains will include Judith Light, Julianna Margulies, Piper Perabo and Peter Hedges. Celebrity Game Night will feature the stars facing off in a series of party games to compete for the coveted title of MCC Game Night Champion.

Matthew Risch & More to Star in A Chorus Line at D.C.'s Signature
A fine company of mega-talents have been selected to lead Signature Theatre's upcoming mounting of A Chorus Line. Matthew Gardiner will direct the previously announced production, which will feature choreography by two-time Tony nominee Denis Jones (Tootsie). The Tony- and Pulitzer-winning musical will play the Arlington, VA theater from October 29, 2019 through January 5, 2020. Heading the cast will be Broadway alum Matthew Risch (Pal Joey) as Zach, with Emily Tyra as Cassie, Joshua Buscher as Larry, Adena Ershow as Val, Samantha Marisol Gershman as Diana, Jeff Gorti as Paul, Ben Gunderson as Bobby, Vincent Kempski as Al, Elise Kowalick as Kristine, Lina Lee as Connie, Bryan Charles Moore as Don, Corinne Munsch as Judy, Kayla Pecchioni as Maggie, Zachary Norton as Greg, Maria Rizzo as Sheila, Trevor Michael Schmidt as Mike, Jillian Wessel as Bebe, Daxx Jayroe Wieser as Mark and Phil Young as Richie.

Broadway-Aimed Havana Music Hall Musical to Hold Industry Presentations
Havana Music Hall, a new musical with an eye on Broadway, will hold industry presentations on November 14 and November 15 in New York City. Featuring a book by Carmen Pelaez and a score by Richard Kagan, Havana Music Hall is set in 1958 at the Havana Music Hall in the heart of a vibrant and creative Cuba. The husband-and-wife team of Rolando and Ramona Calderon are on the verge of a breakthrough when the Revolution tears the only world they have ever known apart. Almost 60 years later, we find the duo trying to forget the past in the now devastated Havana Music Hall, but others won't let them. The November industry presentations will be directed by Elena Araoz.

P.S. Here's your first look at rising star Ruby Rakos in the Judy Garland musical Chasing Rainbows at Paper Mill.

Pandemics are large-scale outbreaks of infectious disease that can greatly increase morbidity and mortality over a wide geographic area and cause significant economic, social, and political disruption. Evidence suggests that the likelihood of pandemics has increased over the past century because of increased global travel and integration, urbanization, changes in land use, and greater exploitation of the natural environment (Jones and others 2008; Morse 1995). These trends likely will continue and will intensify. Significant policy attention has focused on the need to identify and limit emerging outbreaks that might lead to pandemics and to expand and sustain investment to build preparedness and health capacity (Smolinsky, Hamburg, and Lederberg 2003).

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The international community has made progress toward preparing for and mitigating the impacts of pandemics. The 2003 severe acute respiratory syndrome (SARS) pandemic and growing concerns about the threat posed by avian influenza led many countries to devise pandemic plans (U.S. Department of Health and Human Services 2005). Delayed reporting of early SARS cases also led the World Health Assembly to update the International Health Regulations (IHR) to compel all World Health Organization member states to meet specific standards for detecting, reporting on, and responding to outbreaks (WHO 2005). The framework put into place by the updated IHR contributed to a more coordinated global response during the 2009 influenza pandemic (Katz 2009). International donors also have begun to invest in improving preparedness through refined standards and funding for building health capacity (Wolicki and others 2016).

Despite these improvements, significant gaps and challenges exist in global pandemic preparedness. Progress toward meeting the IHR has been uneven, and many countries have been unable to meet basic requirements for compliance (Fischer and Katz 2013; WHO 2014). Multiple outbreaks, notably the 2014 West Africa Ebola epidemic, have exposed gaps related to the timely detection of disease, availability of basic care, tracing of contacts, quarantine and isolation procedures, and preparedness outside the health sector, including global coordination and response mobilization (Moon and others 2015; Pathmanathan and others 2014). These gaps are especially evident in resource-limited settings and have posed challenges during relatively localized epidemics, with dire implications for what may happen during a full-fledged global pandemic.

Pandemics can cause sudden, widespread morbidity and mortality as well as social, political, and economic disruption. The world has endured several notable pandemics, including the Black Death, Spanish flu, and human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) (table 17.1).

Because the definition of pandemic primarily is geographic, it groups together multiple, distinct types of events and public health threats, all of which have their own severity, frequency, and other disease characteristics. Each type of event requires its own optimal preparedness and response strategy; however this chapter also discusses common prerequisites for effective response. The variety of pandemic threats is driven by the great diversity of pathogens and their interaction with humans. Pathogens vary across multiple dimensions, including the mechanism and dynamics of disease transmission, severity, and differentiability of associated morbidities. These and other factors determine whether cases will be identified and contained rapidly or whether an outbreak will spread (Fraser and others 2004). As a result, pathogens with pandemic potential also vary widely in the scale of their potential health, economic, and sociopolitical impacts as well as the resources, capacities, and strategies required for mitigation.

One must distinguish between several broad categories of pandemic threats. At one extreme are pathogens that have high potential to cause truly global, severe pandemics. This group includes pandemic influenza viruses. These pathogens transmit efficiently between humans, have sufficiently long asymptomatic infectious periods to facilitate the undetected movement of infected persons, and have symptomatic profiles that present challenges for differential diagnosis (particularly in the early periods of infection). A second group of pathogens presents a moderate global threat. These agents (for example, Nipah virus and H5N1 and H7N9 influenzas) have not demonstrated sustained human-to-human transmission but could become transmitted more efficiently as a result of mutations and adaptation. A third group of pathogens (for example, Ebola, Marburg, Lassa) has the potential to cause regional or interregional epidemics, but the risk of a truly global pandemic is limited because of the slow pace of transmission or high probability of detection and containment.

Among all known pandemic pathogens, influenza poses the principal threat because of its potential severity and semiregular occurrence since at least the 16th century (Morens and others 2010). The infamous 1918 influenza pandemic killed an estimated 20 million to 100 million persons globally, with few countries spared (Johnson and Mueller 2002). Its severity reflects in part the limited health technologies of the period, when no antibiotics, antivirals, or vaccines were available to reduce transmission or mortality (Murray and others 2006).

During the 1918 pandemic, populations experienced significantly higher mortality rates in LMICs than in HICs, likely as a result of higher levels of malnutrition and comorbid conditions, insufficient access to supportive medical care, and higher rates of disease transmission (Brundage and Shanks 2008; Murray and others 2006). The mortality disparity between HICs and LMICs likely would be even greater today for a similarly severe event, because LMICs have disproportionately lower medical capacity, less access to modern medical interventions, and higher interconnectivity between population centers.

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