Choosing bin settings

[Elena Del Pup]

Hi, 

I want to run HiC-Pro to detect interactions at single gene level. 

I am writing in the case anybody in this group has good advice on how to choose the binning level. 
I am doing metanalysis on other published data. How to approach the choice of a reasonable minimum limit of binning level? 

Also, I often see more bin dimensions be used in studies, including in the default config. Can I also use a single bin dimension instead of multiple? 

If you have some recommendation on best practices for binning Hi-C data that is very welcome. 

Thank you. 

Best regards, 
Elena Del Pup