Hi,
I have been using a single HL2 plus a special 144/28 MHz full duplex "converter" (actually separate up and down converters using the same LO) together with several microwave transverters for some time now. One of these microwave transverters is a full duplex 10GHz input/2.4GHz output with 144 MHz IF. The full duplex works well in the single HL2, have had many contacts on the QO100 satellite. I have separate filters in the Tx and Rx paths at 28 MHz, not using the HL2 filter board as it does not handle the full duplex. The common 116 MHz LO has good isolation between its two outputs (to the Rx and Tx converters) so there is no feedback path that way. I can monitor my 2.4 GHz transmitted signal by listening to the received 10 GHz from QO-100 .
So I can confirm that a single basic HL2 board works well in full duplex mode, but you have to keep the Rz and Tx paths separate. I use the low power tx port.
I have used both Quisk and piHPSDR as SW solutions, they both work very well. I published an article about this in the Finnish Radio Amateur magazine last year, I can make this available if anyone is interested.
73,
Hamish, OH2GAQ