I've been able to make a custom code to run the LDG 1000 Pro II tuner.
It is designed for this type of setup
HL2 (5W) → Pre-drive amplifier (~60W) → Final tube amplifier (~700W) → LDG AT-1000 Pro II → Antenna
You can find the modified code and the uf2 file on my github
https://github.com/Aleziss/HL2IOBoard-LDG-AT1000-ProIIThere are known limitations that are being worked on from Thetis side but it does work on my end.
If you have a different amplifier setup maybe you can try it but all this is provided as is, read the documentation correctly as there are changes from the original code.
Hope it can be helpful to other users !