The Binding Of Isaac Workshop

[Alice Palecek]

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Currently, there is a multitude of CD3 bispecifics with different molecular designs and binding properties in preclinical and clinical development for the treatment of liquid or solid tumors. The key safety concerns with CD3 bispecifics are excessive release of cytokines, which may translate to potentially life-threating cytokine release syndrome (CRS), target organ toxicity due to redirection of T-cells to normal tissues expressing the tumor-associated antigen (TAA) (off-tumor/on-target cytotoxicity), and, in some instances, neurotoxicity. Another key challenge is to arrive at a safe clinical starting dose and an efficient escalating strategy that allows patients in early dose cohorts the potential for clinical benefit in Phase 1 trials. To expand the therapeutic index and bring more treatment options to patients, there are intense efforts to overcome these challenges through improvements in molecular design, preclinical safety assessment strategies, and clinical management practices. A recent workshop at the U.S. Food and Drug Administration (FDA) with industry, academic, and regulatory agency representation was held to discuss the challenges and explore where such improvements to the development of CD3 bispecifics can be implemented. Here, the content of the presentations and the discussion that occurred during this workshop are summarized.

Siebel Center for Design Shop, the iSchool, and the University Library welcome you to join us for an afternoon of fun and creativity as we learn the art of Japanese Stab Binding! During this workshop, you will learn a little about the history of Japanese Stab Binding before you are guided through two different binding patterns: the noble pattern and the hemp pattern. Virtual and in-person attendance options are available!

LEEP students will be able to attend this event online as it will be available live on Siebel Center for Design's YouTube page. The livestream will begin at 12:15 p.m. in order to give in-person attendees time to settle in and grab materials. Online attendees will receive access to a PDF outlining the event and required materials to participate and a link to the YouTube live stream. Register as an online attendee.

In-person attendance will cost $8 to cover the cost of the kit and materials. SCD only accepts credit cards for payments. After the event, attendees will take their kits home to be used for future projects. Register as an in-person attendee. Spots are limited for in-person students, so sign up now!

Like all Lost Art Press books, "Workshop Wound Care" is produced and printed entirely in the United States. The 184-page book is hardbound, 4" x 6-1/2" and printed on bright #70 paper. The pages are sewn and then backed with a fiber tape so the binding will last generations.

Chapter 2: Build a Proper First Aid Kit

Standard first aid kits that you buy over the counter contain some useful items but usually not in proper quantities or of proper quality. Here, you'll learn what you really need.

Chapter 4: Wound Healing Primer

The pathophysiology of wound healing is a series of biochemical cascades; understanding (in plain language) what is happening at a cellular level can give additional insight into expectations of the wound healing process.

Chapter 6: Red Flags

Judging exactly when to seek care after an injury is situation-dependent, but there are certain things which will absolutely necessitate additional care by a medical provider (loss of function, neuromuscular compromise, wound healing, cosmetic concerns).

Chapter 8: Early Wound Care Principles

Appropriate early wound care, and in particular proper irrigation, is important for decreasing the risk of infection. Learn irrigation techniques with a focus on those that have the best evidence for preventing infections.

Chapter 10: So You Cut Your ____ Off? Now What?

Get clear instructions on how to properly store an amputated piece of your body for possible reattachment, as well as immediate care and common treatment of amputations.

Chapter 11: Lacerations

The initial care and triage of lacerations (a common workshop injury) depends on the nature of the wound and what caused the tissue injury. Clean cuts from knives and chisels will generally be easier to manage than tissue-loss injuries caused by power tools.

Chapter 12: Crush Injuries

A misplaced blow of a hammer or dropped workpiece can cause crush tissues and possibly break bones. Learn general triage and pathophysiology of these injuries, with a special focus on subungal hematomas (bleeding/bruising under nails).

Chapter 13: Puncture Wounds

Puncture wounds may appear innocuous but pose the greatest risk in terms of wound infection. The triage of the wounds generally revolves around the site of injury, what caused the puncture and the cleanliness of your skin and the object that punctured you. Splinter management is covered in this chapter.

Chapter 14: High-pressure Injection Injuries

This particular type of puncture wound can seem relatively minor at first, however it can be incredibly devastating, with extensive tissue loss from necrosis that develops in hours and days.

Chapter 15: Eye Injuries

The eye deserves special attention as there is risk of permanent vision loss with some types of injuries. Here you'll learn about corneal abrasions, metal and organic foreign bodies and puncture wounds/open globes.

Montefiascone is a small medieval walled city about 100 k (80 miles) north of Rome, on Lake Bolsena. Since 1988, conservators, curators, art historians, book artists, and others interested in books and their history have come together to work, to learn and to enjoy this special place. Participants come to enjoy the medieval architecture, friendly people, a clean accessible lake, books, and scholarship. The Montefiascone Project is a non-profit making organisation, set up to fund the restoration of the Library of the Seminario Barbarigo in Montefiascone. Participants may attend one, two, three or all four weeks.

For the sake of the local community and everyone associated with the program, we must maintain health and safety standards. We will need to be assured that all course participants comply with Italian regulations concerning vaccinations and other travel requirements.

In England and America, common book structures changed significantly during the early nineteenth century. A typical common calf binding was supplanted by even cheaper, new binding styles, such as paper boards bindings and the three-piece adhesive cloth case. We will examine this time period through PowerPoints, readings, discussions, and the hands-on construction of four models: an English common-boards binding, an American extra-boards binding, an American tight-back cloth binding, and an English cloth case. We will explore methods of replicating plain and textured nineteenth century bookcloth, starting with undyed muslin, which will be useful for conserving and sympathetically rebinding books from this time. Close readings from bookbinding manuals, analysis of bindery images, and the use of historic tools will enhance our understanding of this important and under-appreciated time period.

Kristine Rose-Beers is Head of Conservation at the Chester Beatty in Dublin and an accredited member of the Institute of Conservation. Her research interests include the conservation of Islamic manuscript material, early binding structures and the use of pigments and dyes in medieval manuscripts.

Before moving to Ireland, Kristine worked at the Fitzwilliam Museum in Cambridge as Assistant Keeper (Conservator of Manuscripts and Printed Books); at the Chester Beatty Library with a particular focus on the Turkish manuscript collection; and at Cambridge University Library. She graduated from the Conservation programme at Camberwell College of Arts in 2002 and is a member of the Board of Directors of The Islamic Manuscript Association, and the Kairouan Manuscript Project.

Alison Ohta is currently Director of the Royal Asiatic Society of Great Britain and Ireland. She completed her doctoral thesis at SOAS (London University) on Mamluk bindings and has published and lectured extensively on the subject.

Cambridge, heavily influenced by its university, has always been a place with books at the heart of its activities; a place where they have for many centuries been printed, sold, bound, owned, stored, read, and used. Our Montefiascone course, a few years ago, was devoted to making a model of a late 15th century Cambridge binding; this year we will analyse a binding style from a century later and construct a model of a typical late 16th century Cambridge binding. At the end of the 15th century, leather-covered bindings usually had wooden boards and clasps and decoration depended on labour-intensive repetitive tooling using small hand-held tools. A century later, wood had given way to pasteboard or pulpboard, clasps had been replaced by cloth ties and decoration looked very different; gilt tooling, unknown in English binding work before about 1520, had become common.

The tutors will enable the course participants to make a model binding. Processes will include sewing the text-block, sewing the endbands, shaping and attaching the boards and covering with calf-skin. The covered books will be tooled and have cloth ties attached. The course will be led by a team bringing together the hands-on binding expertise of Jim Bloxam and Shaun Thompson, from Cambridge University Library, and the historical knowledge of David Pearson. David, a binding historian, is currently working on a project to map the development of Cambridge binding between the 15th and 18th centuries, so that Cambridge work can be better recognised and dated. He teaches the evolution of binding styles at the Rare Book Schools in London and Virginia. During the week David will give presentations on ways in which Cambridge binding changed during the 16th century and how it fits into the wider context of British and European binding of the time. He will also consider the value of studying historic bindings, highlighting the questions we should ask.

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