MEDICAL: CONDITIONS: OBESITY : MEDICAL: GENETICS : CHILDREN: HEALTH AND MEDICAL: NATION: Obesity in Some Children Tied to DNA, Study Finds

[David P. Dillard]

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MEDICAL: CONDITIONS: OBESITY :
MEDICAL: GENETICS :
CHILDREN: HEALTH AND MEDICAL:
NATION: Obesity in Some Children Tied to DNA, Study Finds



NATION: Obesity in Some Children Tied to DNA, Study Finds
From news services
December 7, 2009
Chicago Tribune
<http://www.chicagotribune.com/news/chi-tc-nw-briefs-1206-12070dec07,0,673593.story>



-- Some children get severely obese because they lack particular chunks of
DNA, which kicks their hunger into overdrive, researchers report.

The British researchers checked the DNA of 300 children who'd become very
fat, on the order of 220 pounds by age 10. They looked for deletions or
extra copies of DNA segments.




The Times
December 7, 2009
Obese children taken off at-risk register after genes found to be at fault
Mark Henderson, Science Editor
<http://www.timesonline.co.uk/tol/news/uk/health/article6946615.ece>


Two children considered to be at risk of abuse because they are severely
obese have been removed from the protection register after scientists
discovered that they carry a newly identified genetic abnormality that
explains their weight.

Evidence from a ground-breaking study has convinced social workers that
the childrens obesity was not caused by parental neglect or deliberate
overfeeding but by a missing segment of DNA. The cases of another two
children on the at-risk register have also been placed under review, after
research showed them to have the same genetic deletion.


<snip>


We found five children with this deletion, and when we got in touch with
their families with the results we found four had been put on the at-risk
register, said Sadaf Farooqi, of the University of Cambridge. Were at
various stages of discussions with social services. Two of the children
have already been taken off the register, and were optimistic about the
other two cases.


<snip>


The study, published in the journal Nature, is the first to identify a
link between obesity and a genetic variation in which segments of DNA are
deleted or duplicated.

The researchers, led by Dr Farooqi and Matt Hurles, of the Wellcome Trust
Sanger Institute,compared the DNA of 300 children who developed severe
obesity before the age of 10 with that of more than 7,000 apparently
healthy volunteers.



Missing genes identified as obesity trigger
Updated December 7, 2009 11:47:28
Australia Broadcasting Corporation (ABC)
Radio Australia
<http://www.radioaustralia.net.au/
connectasia/stories/200912/s2763843.htm>


A shorter URL for the above link:


<http://tinyurl.com/ykwt8lj>




Obesity gene discovery 'may cut cases blamed on abuse'
Child obesity levels have been rising for decades
Scientists have discovered what they believe is a genetic cause of severe
obesity in children.
BBC News
<http://news.bbc.co.uk/2/hi/health/8394991.stm>


The team concluded that the loss of a key segment of DNA can be to blame.

It said the findings might improve diagnosis of severe obesity - which on
occasion has been wrongly attributed to abusive overfeeding.

The study, of 300 children with severe obesity by the University of
Cambridge and the Wellcome Trust Sanger Institute, appears in Nature.

Some of the children in the study had been formally placed on the social
services 'at risk' register on the assumption that their parents were
deliberately overfeeding them. They have now been removed from the
register.

Obesity is increasing throughout the world and is recognised as a major
global public health concern.

Although much of the problem is due to lifestyle factors such as an
unhealthy diet, and lack of exercise, some cases are thought to be down to
genetics.

The latest study examined each child's entire genome, looking for
deletions or duplications of DNA, known as copy number variants (CNVs).

Experts increasingly believe these CNVs play an important role in genetic
disease.




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The complete articles may be read at the URLs provided for each.



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