428 CMAAO CORONA FACTS and MYTH 24th April Post Vaccine Covid
Dr K K Aggarwal
428 CMAAO CORONA FACTS and MYTH 24th April Post Vaccine Covid
Dr K Aggarwal President CMAAO, HCFI,
With input from Dr Monica Vasudev
1570: Post vaccine covid
- In the CDC's Morbidity and Mortality Weekly Report, health officials described 22 "breakthrough" infections diagnosed among nearly 15,000 Chicago-area nursing home residents and staff two weeks or more after they received a second mRNA COVID vaccine dose
- At one Kentucky nursing home, 22 out of 127 residents and staff developed infections at least two weeks after their second mRNA vaccine dose, with virus sequencing indicating an unusual variant was responsible, according to a separate MMWR report
- And among 417 employees and students at Rockefeller University in New York City receiving two mRNA vaccine doses, researchers identified two breakthrough infections -- notable mainly for the particular virus strains involved, as reported in the New England Journal of Medicine
They're more common, however, among older individuals, and the vaccines do not offer complete protection against serious illness or death.
Chicago-Area Investigation
February to March 31.
627 confirmed SARS-CoV-2 infections were detected in 75 nursing homes
1. 447 of which were in residents and staff who had not been vaccinated at all.
2. 145 were in individuals who had received only one dose
3. 13 involved individuals who hadn't completed two weeks from their second shot.
Among the 22 with definite breakthrough infections, 12 were in residents and 10 in staff. Fourteen cases were asymptomatic, four required hospitalization, and one proved fatal. The resident who died also had a bacterial bloodstream infection as well as a urinary tract infection, plus multiple chronic conditions known to increase risk for severe COVID-
Kentucky Nursing Home
Vaccination program was completed Feb. 21.
90% of the facility's 83 residents and just over half of the 116 staff members had received two doses of the Pfizer/BioNTech vaccine.
On March 1, the first case of what became an outbreak was detected in an unvaccinated staff member via antigen testing. Over the next several weeks, 18 residents and four additional staff members were found to be infected, all more than two weeks after their last vaccine dose.
Twelve of the cases among residents were asymptomatic; two involved hospital admission, and one resident died. Two staff members developing breakthrough infections developed symptoms that did not require hospitalization.
Sequenced virus isolates from 27 cases at the facility and determined that these were an unusual strain known as R.1.
It includes mutations such as E484K
Rockefeller University
Jan. 21, when two weeks had elapsed since the first vaccinees had received their second doses of either the Pfizer/BioNTech or Moderna vaccines
Began looking for breakthrough cases, with 417 individuals considered eligible.
By March 17, the group found two: both in previously healthy women, one age 51 and the other 65, who developed mild symptomatic illness 19 and 36 days, respectively, after their second vaccine doses.
Viral RNA sequencing showed that both women were infected with variants differing from each other as well as from the original Wuhan strain. In "Patient 1" the virus included the E484K mutation and another known as D614G, whereas virus from "Patient 2" had D614G plus S477N. Both were distinct from variants such as B.1.1.7 and B.1.526 known to be circulating in New York City.