432 CMAAO CORONA FACTS and MYTH 28th Steroids and Vaccine

[Dr K K Aggarwal]

432 CMAAO CORONA FACTS and MYTH 28th Steroids and Vaccine

 

Dr K Aggarwal President CMAAO, HCFI

With input from Dr Monica Vasudev

 

1573:

1.    Although there's no direct evidence to suggest that corticosteroid injection before or after an adenovirus vector-based COVID-19 vaccine decreases vaccine efficacy, clinicians may still want to time elective corticosteroid injections at least two weeks before or after receipt of this vaccine, according to a group of doctors writing on behalf of the Spine Intervention Society.

2.    The two-week rule of thumb is based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following intraarticular and epidural corticosteroid injections, researchers argue in a paper published in Pain Medicine.

3.    Two weeks is also based on the timeline of reported peak efficacy of the Janssen and AstraZeneca adenovirus-vector-based COVID-19 vaccines

4.     An early analysis of phase 1-2a and phase 3 trial data found the Janssen COVID-19 vaccine elicited cellular and humoral immune responses and conferred clinical protection as soon as 14 days after administration, while the AstraZeneca vaccine had findings 15 days after the second dose

5.     In the Janssen phase 3 trial, corticosteroid use was allowed at or below the equivalent of 20mg/day via ocular, topical or inhaled administration

6.     Topical or inhaled steroids were permitted in the AstraZeneca trials for up to 14 days.

 

SOURCE: https://bit.ly/3gFPHAl Pain Medicine, online April 11, 2021.

 

 

1574: The Pfizer-BioNTech and Moderna COVID-19 vaccines appear to be effective against the B.1.526 variant first identified in New York, according to The New York Times.