The "right" way to do this would be something like this:
First, you have to know the target resolution for your game when it's "scaled up". Let's say I want it to be 800x400.
So, you go to your Project.xml and put in these values on the window tag:
<window width="800" height="400" fps="60" background="#000000" hardware="true" vsync="true" />
Now, we should calculate your scale factor. Your original tileset has 16x16 tiles, and you want them to be 64x64. That's a 4 scale factor for your game.
So, your game size should be 800/4 x 400/4 => 200x100. Now, go to Main.hx and put in these values on the following variables:
var gameWidth:Int = 200;
var gameHeight:Int = 100;
I think that should do it. ;)