"Better" in what way? Better for memory consumption? Sure, but that's unlikely to be a big issue in the first place. Better for rendering performance? As long as everything needed is on the same spritesheet, that shouldn't really affect the amount of drawTiles calls.
Perhaps it's worth it if you're targeting mobile devices that have a low max texture resolution (2048x2048 or even 1024x1024) and you wouldn't be able to fit everything on that otherwise. Then again, you would need to split them up either way in that case.