Affinity Portugal

[Octavis Marquez]

IEEEaffinity groups are non-technical subunits of one or more Sections or a Council. An affinity group is a local unit of an IEEE organizational unit or standing committee, established by petition to the parent organizational unit, to fulfill the purposes of IEEE.

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Laminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behavior. However, the site-specific immobilization of this heterotrimeric glycoprotein and, consequently, control over its orientation and bioactivity has been a challenge that has limited many of the explored strategies to date. In this work, we established an affinity-based approach that takes advantage of the native high affinity interaction between laminin and the human N-terminal agrin (hNtA) domain. This interaction is expected to promote the site-selective immobilization of laminin to a specific substrate, while preserving the exposure of its key bioactive epitopes. Recombinant hNtA (rhNtA) domain was produced with high purity (>90%) and successfully conjugated at its N-terminal with a thiol-terminated poly(ethylene glycol) (PEG) without affecting its affinity to laminin. Self-assembled monolayers (SAMs) of mono-PEGylated rhNtA on gold (mPEG rhNtA-SAMs) were then prepared to evaluate the effectiveness of this strategy. The site-specific immobilization of laminin onto mPEG rhNtA-SAMs was shown to better preserve protein bioactivity in comparison to laminin immobilized on SAMs of thiol-PEG-succinimidyl glutaramide (HS-PEG-SGA), used for the non-selective covalent immobilization of laminin, as evidenced by its enhanced ability to efficiently self-polymerize and mediate cell adhesion and spreading of human neural stem cells. These results highlight the potential of this novel strategy to be used as an alternative to the conventional immobilization approaches in a wide range of applications, including engineered coatings for neuroelectrodes and cell culture, as well as biofunctionalization of 3D matrices.

Judging from the numerous books launched by Eurasian authors on their heritage and family history, it seems that the Eurasian community in Singapore has a general strong interest in research on genealogy, which in itself makes for interesting study due to a mixture of cultures, ethnicities and even traditions in cuisine.

The Portuguese with their sense of inherent adventure, had close ties to the East India trades already in the early 1600s. It is probably these factors in combination that landed the Cordero / Cordeiro family in East Asia in the first place. The genealogy of the Cordeiros can be traced from the highlands of Andalusia in Spain during the Medieval times, to the autonomous archipelago of the Azores of Portugal (ca. 1600ff), right through to Macau (ca. 1800ff) and then to Singapore during the early 1900s. To that extent, one could argue that the Cordeiros have flown flags of many colours, the most prominent (for the older generations of the family) being the vibrant colours of Portugal.

As with today when it is said that Italy plays no small role as a global economic source of influence, intriguing stories of adventure, mutiny and piracy in firsthand account of what happened to one set of such kraak cargo onboard the Portuguese ship So Tiago in 1602 can be found by Italian Florentine Merchant Francesco Carlett in his Codex 1331 (T.3.22) preserved in the Biblioteca Angelica in Rome. A XVIIth Century Manuscript, known as Ragionamenti del mio viaggio intorno al mondo (modern print 1964), this book also describes the fantastic stories of a man who had tried to facilitate the exchange of goods between the Far East and Europe, and after 15 years spent circumnavigating the globe (the first ever of its kind documented) beginning from Cadz Spain, he arrived home in Firenze with nothing except his manuscript.

Even if family history reveals an affinity for coastal regions, the Swedish west coast offers somewhat of a different reality to the equatorial beaches, not in the least because of climate or temperatures, but of colours and sounds.

The reason for the similarities in the words Saga, sga and say is that the English language group stems from the northern Indo-European (IE) language family, also called Proto-Germanic, that was originally spoken in approximately the mid-1st millennium BC in Iron Age northern Europe (Baugh & Cable 2003, Barber 1993, Bjrkman 1978, Geipel 1971, Walshe 1965). Along with all of its descendants it spread with the Germanic peoples moving south from northern Europe in the 2nd century BC, to settle in north-central Europe and from then over to Great Britain, North America, Australia to settle as its most modern and contemporary varieties of New Englishes, where Singlish or Singapore Colloquial English in the Republic of Singapore is but one of them (Wee 1998, Gupta 1994,1992, Kwan-Terry 1978).

Alice fell silent for a moment, having not a clue what the Hatter was on about. But she was so very fond of him and his galumphing madness that she gave what he said a thought. Besides, the best people often are off their heads, as such, incapable of getting lost.

The following list details 12 different language affinity groups that form the focus of Lingu Christi's work. The groups are largely based on linguistic family groups and as such they provide a natural framework for team-based, incarnational missions.

Millions of people speak indigenous minority languages across the Iberian Peninsula, stretching from Portugal in the west, across Spain, and into the southwestern regions of France. Both Catalan in the east and Galician in the west have speakers numbering in the millions individually with many other groups between them. The Basque language continues to puzzle linguists and historians who search for how it arrived in the western Pyrenees.

The Female Faculty Aligned with Business (FFAB) affinity group held its first event, titled "Empowering Women in Education" event at the Lundring Event Center on March 20, 2024. The gathering attracted a remarkable turnout of women and those who identify as female from across the university, including full-time and adjunct faculty members. The event was distinguished by Dr. Victoria Crittenden's keynote address. As Professor of Marketing at Babson College and Editor of the Journal of Marketing Education, she delivered an empowering speech that delineated the essence of empowerment for female faculty and underscored the significance of mentorship within academia. This event has established a solid foundation for the university's commitment to support and honor the essential contributions of women in academia. For further details about joining FFAB and forthcoming events, please reach out to any member of the leadership team: Mary Jo Shane, Carol Swett, Tracy Nickl, Annie Denq, or Setayesh Sattari who must all be sincerely thanked for their energy and time in making this happen!

A predominant symptom of nicotine withdrawal is cognitive deficits, yet understanding of the neural basis for these deficits is limited. Withdrawal from chronic nicotine disrupts contextual learning in mice and this deficit is mediated by direct effects of nicotine in the hippocampus. Chronic nicotine treatment upregulates nicotinic acetylcholine receptors (nAChR); however, it is unknown whether upregulation is related to the observed withdrawal-induced cognitive deficits. If a relationship between altered learning and nAChR levels exists, changes in nAChR levels after cessation of nicotine treatment should match the duration of learning deficits. To test this hypothesis, mice were chronically administered 6.3mg/kg/day (freebase) nicotine for 12 days and trained in contextual fear conditioning on day 11 or between 1 to 16 days after withdrawal of treatment. Changes in [(125)I]-epibatidine binding at cytisine-sensitive and cytisine-resistant nAChRs and chronic nicotine-related changes in ?4, ?7, and ?2 nAChR subunit mRNA expression were assessed. Chronic nicotine had no behavioral effect but withdrawal produced deficits in contextual fear conditioning that lasted 4 days. Nicotine withdrawal did not disrupt cued fear conditioning. Chronic nicotine upregulated hippocampal cytisine-sensitive nAChR binding; upregulation continued after cessation of nicotine administration and the duration of upregulation during withdrawal paralleled the duration of behavioral changes. Changes in binding in cortex and cerebellum did not match behavioral changes. No changes in ?4, ?7, and ?2 subunit mRNA expression were seen with chronic nicotine. Thus, nicotine withdrawal-related deficits in contextual learning are time-limited changes that are associated with temporal changes in upregulation of high-affinity nAChR binding.

This demo shows how airline digital experts can design affinity shopping on the airline website using PROS Shopping solutions. Affinity shopping makes it easy for travelers to search for flights based on their trip or budget preferences, while increasing online conversion and driving more direct bookings for the airline.

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