Results: miRA is a new tool to identify miRNA precursors in plants, allowing for heterogeneous and complex precursor populations. miRA requires small RNA sequencing data and a corresponding reference genome, and evaluates precursor secondary structures and precursor processing accuracy; key parameters can be adapted based on the specific organism under investigation. We show that miRA outperforms the currently best plant miRNA prediction tools both in sensitivity and specificity, for data involving Arabidopsis thaliana and the Volvocine algae Chlamydomonas reinhardtii; the latter organism has been shown to exhibit a heterogeneous and complex precursor population with little cross-species miRNA sequence conservation, and therefore constitutes an ideal model organism. Furthermore we identify novel miRNAs in the Chlamydomonas-related organism Volvox carteri.
On reaching Maggie's, Shaun and company learn that most of the country has been locked down following massive outbreaks along the Gulf Coast: a Second Rising. Shaun figures out that the cause is not an airborne strain of live virus as most fear, but it is now being transmitted by mosquitoes. He confirms this with Dr. Abbey and receives an offer to join her in Shady Cove, Oregon. Shaun and Mahir organise the rest of the site's staff to propagate what they have learned, before those at Maggie's evacuate. Shortly before reaching Shady Cove, Shaun is attacked and bitten, and is quarantined in Abbey's lab. Despite several tests, he shows no sign of becoming a zombie. The novel's coda reveals that despite her apparent death, Georgia is somehow alive and well in an unknown CDC facility.
Without the framing device of a United States presidential election to use as in Feed (waiting for the next election would have left too much time for the characters' emotional wounds to heal), McGuire chose to focus more on the zombie virus itself: how a lab-engineered virus developed and evolved, and how humans were responding to it, on both societal and biological levels.[1] McGuire also wanted to address the long-term impact of a zombie apocalypse on society and the associated psychological ramifications.[1] Other themes covered in the novel include medical ethics and human responsibility.[2][3]
Deadline was published in May 2011.[4] The novel was originally to be titled Blackout, but this was changed shortly before publishing to avoid confusion with Connie Willis' novel Blackout (2010), published a year earlier.[4] Grant instead used Blackout as the title for the third Newsflesh novel.[4]
In reviewing the novel for SFFWorld, Rob Bedford described the book as avoiding the pitfalls normally associated with the middle work in a trilogy and praised McGuire's strong pacing despite the novel's length.[2] Bedford also compliments the author's treatment of the subject of medical ethics (particularly in extreme situations) as well handled and thought-provoking.[2] Selena MacIntosh of Persephone Magazine noted several improvements over Feed, particularly tighter plotting and storytelling, along with deeper characters.[5] However, as MacIntosh was less impressed overall with the first novel, she passes some of the credit for Deadline's success to a new editor McGuire notes was previously uninvolved.[5] In the Seattle Post-Intelligencer, Brian Fitzpatrick wrote McGuire takes the "political intrigue of Feed and ratchets it up to 11" and highly praised the novel's conclusion.[6] He also states that the use of zombies as the means of a hidden agenda make the work scarier than the straightforward "humans versus zombies" scenario in other zombie fiction.[6]
Mira, Mirror is a 2004 young adult fantasy novel written by Mette Ivie Harrison.[1] The story of the novel is told from the viewpoint of the magic mirror from the fairy tale "Snow White".[2] "Mira" is a main character.
Mira, Mirror received mixed reviews. Kirkus Reviews gave an unfavorable review stating: "Purporting to explore weighty issues between sisters, of magic, power, and love, this weakly executed and excruciatingly tedious tale falls short."[3] Praising the book for its story and writing, author and critic, Orson Scott Card said of the book: "I cannot recommend this novel highly enough."[2] The New England Science Fiction Association reviewed the book as "enjoyable".[4]
Feed is the first book in the Newsflesh series of science fiction/horror novels written by Seanan McGuire under the pen name Mira Grant and published by Orbit Books in 2010. Set during the aftermath of a zombie apocalypse and written from the perspective of blog journalist Georgia Mason, Feed follows Georgia and her news team as they follow the presidential campaign of Republican senator Peter Ryman. A series of deadly incidents leads Georgia and her brother Shaun to discover efforts to undermine the campaign, linked to a larger conspiracy involving the undead.
The novel's narration then changes to Shaun's perspective. He rallies Ryman's security detail to help contain the outbreak, then breaks into the convention centre to confront Ryman and Tate. Tate takes Ryman's wife hostage with a syringe of the zombie virus, claiming his actions were part of a plot using fear of the zombies to reshape America into a more faith-based society. Then the governor injects himself instead, and Shaun shoots him to prevent zombification.
The inspiration to write Feed came from the combination of McGuire's interests in horror movies and virology.[2] McGuire wanted a zombie virus that was society-changing but survivable, and spent two years developing the concepts of the virus and its consequences.[2] Another aspect McGuire wanted to tackle was the apparent lack of awareness horror fiction characters had of horror fiction canon: in her novel, movies like Dawn of the Dead (1978) are credited with helping the human race survive.[2]
Zack Handlen's review of the novel for The A.V. Club describes Feed as "The West Wing by way of George Romero".[3] He singles out the level of detail in McGuire's worldbuilding for praise, and he observes that although most of the cast are stock characters, this is not a major obstacle in enjoying the book's narrative.[3]
Feed was listed as number 74 in NPR's 2010 "Top 100 Killer Thrillers" poll.[6] The novel was nominated for the 2011 Hugo Award for Best Novel, and came second in that category, behind Blackout/All Clear (2010) by Connie Willis.[7][8]
Seanan McGuire (pronounced SHAWN-in;[1] born January 5, 1978, in Martinez, California) is an American author and filker. McGuire is known for her urban fantasy novels. She uses the pseudonym Mira Grant to write science fiction/horror[2] and the pseudonym A. Deborah Baker to write the "Up-and-Under" children's portal fantasy series.[3]
In 2010, she was awarded the John W. Campbell Award for Best New Writer by the World Science Fiction Convention.[4] Her 2016 novella Every Heart a Doorway received a Nebula Award,[5] Hugo Award,[6] Locus Award,[7] and Alex Award.[8]
Rosemary and Rue was her first published novel, released in 2009. She published Feed under the pseudonym Mira Grant in 2010, thus establishing herself as an urban fantasy writer and her Grant persona as a horror/science fiction writer.
Parasite is a finalist for the 2014 Hugo Award, the fourth Best Novel nomination for Mira Grant. Its sequel, Symbiont, will be published in fall 2014, with the third book in the Parasitology series currently scheduled for fall 2015. The first two Newsflesh novellas are slated for release in Summer 2014 and Summer 2015, respectively.
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The novel opens in Alicante when René is asked to give a lecture at his friend's tertulia on a famous novel, La luna roja, by the Turkish author Emil Kemal, whose work René translated years ago. René, a once famous but currently frustrated author who is relegated to writing magazine articles and cannot seem to pen a new novel, agrees to attend but proceeds to argue with one of the participants about the details of Kemal's life. The young woman, Aurelia, insists that René knows nothing about the Turkish author's life and that La luna roja was written after the author suffered heartbreak from his relationship with the Sephardic Jew, Orpa. Soon afterward, René receives a mysterious phone call in Turkish from an unknown woman asking him to help Emil Kemal, whose life is in grave danger. René rushes to his apartment, where he finds the renowned author dead on the floor with a book of René's resting on his chest. The book is not the one that René had dedicated to Kemal but the one directed to Kemal's wife and René's lover, Derya, to whom René expresses his ardent desire. René is forced to confront his repressed (he had not seen Kemal for eleven years prior to the mysterious phone call) and [End Page 162] unresolved past with Kemal and Derya. He must also reconcile with his youth in Turkey and his obsession with Tuna, his first real love. René begins to receive copies of Kemal's diaries from the mysterious woman, Aurelia, and finds himself embroiled in the Turkish author's past. Aurelia insists that René, as an expert of his works and friend of Kemal, must write his history so that the world can know what happened to the enigmatic author. René is forced on a journey of self-discovery both in Germany and Turkey while trying to solve the mystery that was Emil Kemal's life. It is fascinating to observe how René, who is used to navigating various cultures, identifies himself and how his identification is based on his relationships with the people in each country rather than the country itself.
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