leading edge analysis Result

[mehwish]

After performing the GSEA , leading edge analysis , I got four plots , in the clustered heat map box , when I save the dataset option its showing the genesets , and genes names and there are some values under  each gene, Can anybody confirm what exactly that value is representing?? is that the enrichment score of that gene in that particular geneset?

Thanks

Mehwish

[mehwish]

I am trying to explore the leading edge analysis. can you please share any good reading resource, I couldn't find any other than how it is performed.

All what I have understood is that it makes a subset of the genes that are prominently playing part in the enrichment score of the geneset.

How is it different than the genes identified at the geneset html page , below the enrichment map of the geneset. 

Thanks

[Anthony Castanza]

The results page for a given set shows the leading edge for a particular set. The leading edge analysis tool examines the leading edge from all the sets that you select to find common clusters of genes between them. This can help with identification of common core driver genes.

-Anthony

Anthony S. Castanza, PhD
Curator, Molecular Signatures Database
Mesirov Lab, Department of Medicine
University of California, San Diego

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[mehwish wahid]

Thankyou so much for your reply Anthony , really appreciate your help.

Thanks 

Mehwish 

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