Is it possible gene set enrichment analysis?

[Hari Shankar Gadri]

Hi everyone

I have only gene symbols and gene names. Is it possible gene set enrichment analysis? If it is possible how can it perform.

[Anthony Castanza]

Hi Hari,

Unfortunately no, the GSEA method, like all true enrichment tests, requires expression data not just gene lists. The best you can do with a simple gene list is an overlap statistic test like what you can do through the MSigDB web tools, or other 3rd party tools.

-Anthony

Anthony S. Castanza, PhD
Curator, Molecular Signatures Database
Mesirov Lab, Department of Medicine
University of California, San Diego

On Sat, May 11, 2024, 6:38 AM Hari Shankar Gadri <haribot...@gmail.com> wrote:

Hi everyone

I have only gene symbols and gene names. Is it possible gene set enrichment analysis? If it is possible how can it perform.

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