Hi, we ran into the same issue packaging a Python application for ppc64le and s390x. We attempted building grpcio from source using GRPC_PYTHON_BUILD_SYSTEM_OPENSSL=1 and it compiled successfully, but took over 1 hour under QEMU emulation, making it impractical for a CI/CD packaging pipeline.
Has anything changed since 2022 regarding official ppc64le/s390x wheel support, or plans to publish pre-built wheels for these architectures?