I'm still not 100% sure I understand, but I'll try to clarify my assumptions as I go.
> when we want to serialize the we sent it to the protoserrializer file
I'm assuming this means that you're using a
custom response serializer via this keyword argument of the RpcMethodHandler class. "protoserializer" is not a file I am familiar with in either the gRPC or protobuf projects, so I'm guessing this is your own file and probably your custom serializer.
I'm not sure why you would be using a custom serializer if all you want to do is serialize protobufs though. That's the behavior of the default serializer.
> why does function call only when server get refresh it whenever I invoke the API request at that my serializer does not call
I'm really not sure what you mean by "refresh" here. gRPC servers have no refresh method. If you are using your own RpcMethodHandler with a custom response serializer, then it will be invoked every time you return a response in your server handler.
> about the custom method Serializer
The capitalization of "Serializer" here is throwing me. There is no "Serializer method" in the gRPC Python API surface, nor do we have any methods that are capitalized, but individual proto files _do_ capitalize all of their methods. Is this a particular RPC method that your or another member of your organization has written into a proto file?