Biochemical And Cellular Archives

[Elwanda Menhennett]

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The goal of this review is to place the exciting advances that have occurred in our understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical and physiological context. We review new data regarding the mechanism of selenoprotein synthesis, the molecular and cellular biological properties of the individual deiodinases, including gene structure, mRNA and protein characteristics, tissue distribution, subcellular localization and topology, enzymatic properties, structure-activity relationships, and regulation of synthesis, inactivation, and degradation. These provide the background for a discussion of their role in thyroid physiology in humans and other vertebrates, including evidence that D2 plays a significant role in human plasma T(3) production. We discuss the pathological role of D3 overexpression causing "consumptive hypothyroidism" as well as our current understanding of the pathophysiology of iodothyronine deiodination during illness and amiodarone therapy. Finally, we review the new insights from analysis of mice with targeted disruption of the Dio2 gene and overexpression of D2 in the myocardium.

See the University Class Schedule and University Course Catalog for more information on when courses in the Department of Biology are offered, and for additional courses that are offered on demand. Information on the schedule for registration is available from the University Academic Calendar.

BIOL 100 - Biological Science. 4.000 Credit hours

This is a general education course that stresses the objectives presented under the general education program of the University. This course stresses central concepts in biology including; basic chemical and physical phenomena, biochemistry, cell form and function, genetics, evolution, and multicellular organization. The laboratory will examine major biological concepts. Biological Science is open to non-Biology majors.

BIOL 101 - Concepts in Biology I. 4.000 Credit hours

This course is an introduction to science and the scientific method, basic biochemistry, cell structure and function, energy and metabolism, reproduction and genetics for those students planning to enroll in additional major courses in the biological sciences. The laboratory will emphasize central biological concepts. Corerequisite: CHEM 103 or CHEM 106

BIOL 102 - Concepts of Biology II. 4.000 Credit hours

This course is a continuation of BIOL 101. It will include an introduction to evolution, basic ecological principles, and a survey of the diversity of life. The laboratory will survey life's diversity. Prerequisite: BIOL 101.

BIOL 105 - Biology Orientation I. 1.000 Credit hours

This course will introduce students to the university and the Department of Biology. Special emphasis will be placed on succeeding as a biology major, the challenges and expectations, effective study skills, university support services, and university policies and procedures. Students are expected to leave the course with an awareness of how to cope with and overcome the demands of college life and to take advantage of opportunities at the university. Restricted to biology majors. Prerequisite: None.

BIOL 200 - Introduction to Research. 3.000 Credit hours

This course will offer an introduction to the basic principles of biological research. It will emphasize reading biological research literature, writing and verbal communications in scientific formats, the scientific method, and research ethics. The laboratory will emphasize hypothesis development, experimental design, data analysis, basic laboratory techniqques, and the application of mathematics in the laboratory. Students are expected to leave the course with the ability to read primary literature, properly design and perform hypothesis-driven experiments, and effectively communicate and interpret results. Prerequisites: BIOL 102.

BIOL 205 - Biology Orientation II. 1.000 Credit hours

This course is a continuation of BIOL 105. Emphasis will be placed on effective study skills, career planning, professional development, university support services, and university policies and procedures. Students are expected to leave the course with an awareness of career options in the biological sciences, requirements for pursuing advanced studies, and job-seeking skills. This course is restricted to biology majors. Prerequisites: BIOL 105 or FRST 100, Biology Major.

BIOL 210 - Writing in Biology. 3.000 Credit hours

This course will teach students the fundamentals of effective scientific writing. Instruction will focus primarily on the process of writing and be presented in two parts. Part I will teach students the rules of writing and how to write effectively, concisely, and clearly. Part II will emphasize scientific writing, including manuscript and grant preparation. Students will attend weekly lectures, during which they will complete writing assignments and editing exercises using prepared handouts and Criterion. Prerequisites: BIOL 102, Biology Major.

BIOL 221 - General Microbiology. 4.000 Credit hours

This is an introduction to the basic principles of microbiology. Microbial ultrastructure, growth, metabolism, molecular genetics, diversity, infectious diseases, and immunology will be discussed. The laboratory introduces students to the principles of microscopy, specimen preparation for light microscopy, aseptic techniques, cultivation techniques, and the biochemical activities of microorganisms. Prerequisites: BIOL 100 or 101, CHEM 104 or 106.

BIOL 276 - Phage Laboratory I. 2.000 Credit hours

Research-based course in which students isolate and purify bacteriophages from environmental samples, visualize the phages with electron microscopy, and isolate phage DNA for genomic sequencing. Prerequistes: BIOL 102 or permission of instructor.

BIOL 277 - Phage Laboratory II. 2.000 Credit hours

Research-based course in which students annotate sequenced genomes from bacteriophages isolated in BIOL 276. Genome sequence files are finished, oriented, evalauted and analyzed. Finalized files are reviewed for submission to GenBank. Post-annotation experimentation and research may also be carried out. Prerequisites: BIOL 102 or permission of instructor.

BIOL 301 - Molecular Biology. 4.000 Credit hours

This course examines the molecular events in cell function using molecular genetics, cell biology, and fundamental biochemistry; using both prokaryotic and eukaryotic systems. The laboratory will emphasize fundamental techniques used in molecular biology. Prerequisites: BIOL 221, CHEM 107 and 117.

BIOL 304 - Pre-Medical Preparation. 3.000 Credit hours

This course exposes students to health professionals and their respective health care professions through seminars, field trips, internships, test preparations, medical ethics, and clinical research. Prerequisites: Biology major, junior level.

BIOL 305 - Cell Biology. 4.000 Credit hours

This course examines, in detail, the biology of the eukaryotic cell. The course will focus on the functions of the plasma membrane, organelles, and macromolecules within the cell. The course will also cover cellular growth, division, and cell death. The laboratory will include exercises to visualize the cell and to measure the physical and chemical properties of cellular macromolecules. Prerequisites: BIOL 221, CHEM 107 and 117.

BIOL 325 - Evolutionary Biology. 3.000 Credit hours

This course introduces students to the core concepts of organic evolution. It examines the basic evidence supporting organic evolution and emphasizes phylogenetic analysis, microevolutionary mechanisms of genetic change, and speciation. It also demonstrates the role of evolutionary biology in addressing the variety of phenomena observed in the organic world. Prerequisites: BIOL 102, BIOL 466.

BIOL 342 - Current Topics in Biology. 3.000 Credit hours

This course will explore, in depth, a comparatively narrow subject which may be topical or of special interest. Emphasis is placed on emerging and cutting edge ideas. Because the topics change each time the course is offered, this course may be repeated once for additional credit. For the same reason, a failing grade cannot be replaced by retaking the course. Prerequisites: BIOL 102, CHEM 107.

BIOL 350 - Human Anatomy and Physiology I. 4.000 Credit hours

This course, which provides a comprehensive study of the anatomy and physiology of the human body with an emphasis on health and medical issues, is designed for biology majors and/or students preparing for careers in the health professions. It will include an overview of organ systems, basic chemical organization, cell structure and function, and tissues; followed by the study of the skeletal, muscular, and nervous systems. The laboratory includes studies of histology, physiology experiments, model studies, computer simulations, and multimedia presentations. Prerequisites: BIOL 100 or 101, CHEM 103 or 104 or 106.

BIOL 351 - Human Anatomy and Phys II. 4.000 Credit hours

This course is a continuation of BIOL 350 and expands a comprehensive study of the anatomy and physiology of the human body with an emphasis on health and medical issuses. Lecture topics include special senses, the endocrine system, cardiovascular and respiratory physiology, immunity, digestion, nutrition and metabolism, the urinary system, and the male and female reproductive systems. Laboratory work includes physiology experiments, model studies, computer simulations, and multimedia presentations. Prerequisite: BIOL 350.

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