In this case the volume is discretized in Yee Cells, so, you discretize this integral moving through the Yee cells. For example, imagine the cell at coordinate (is, js, ks). This coordinates are normalized, that is, they are the points in space normalized by the discretization (is, js, ks are natural numbers). You want to calculate the voltage diference between this coordinate and (is, js+1, ks), that is, moving one cell in the y direction (if Deltay is the discretization in the y direction this would be the voltage difference by moving Deltay in space. The following drawing shows how to do this:
In the cell (is, js, ks) you have the field Ey which lies on the vertex between (is, js, ks) and (is, js+1, ks). So the line integral becomes simply the product of the field Ey at coordinate (is, js, ks) and the spatial discretization Deltay.
If your voltage calculation is over a more complicated path, you should repeat this procedure over the whole path.
Best regards,
Andres