I'm having a lot of issues with this too. It will run fine for a number of hours, but often by the end of the day, I can't load up the website because the plugin never even contacts the server. I have to re-start Chrome to get things working again. It is really not ideal.
I've briefly looked at super-dev-mode, but I haven't seen a simple tutorial on how to set it up or use it effectively. I guess that these Chrome plugin issues are the whole reason that super-dev-mode is being worked on.