Hi Nickolas,
A good overview of the NGINX buffering mechanism can found on this third-party website. As described, “When buffering of responses from the proxied server is enabled, and the whole response does not fit into the buffers set by the proxy_buffer_size and proxy_buffers directives, a part of the response can be saved to a temporary file.”. Therefore, it will be important to look at the response generating these warning and check for any inconsistencies to determine if something is wrong with the App Engine Flexible environment. Also, determining if this warning is linked to any particular handler or endpoint may give additional insight to the root cause. Would you be able to provide some sort of stack trace of the response?
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