Currently App Engine does not support incoming gRPC connections (also
listed here as a limitation for App Engine endpoints communications). The engineering team is aware of this and are working hard on providing a solution for gRPC use.
In the meantime, outbound client support for gRPC is available, and can be seen in use by the
Google Cloud Client Libraries. These official libraries are being developed to support outbound requests via gRPC to Google Cloud services from any client environment (including App Engine, e.g
shown here for Java 8).