We have a google app engine app serving a custom domain (https). The setup has been working for over 2 years now (initially it was http and we shifted to https around 6 months ago). Past one month we are facing intermittent issues of pages timing out/long delays (over 20-30 seconds to load instead of usual 1-2 seconds). When we access our app directly via the appspot url, it works consistently.
https://ipdb.at/ip/74.125.200.121ghs.googlehosted.com