Hello
Currently Google is advising customers to use tools specific to Python rather that being dependent on dep_appserver. To test Datastore in your local environment, you can use the Datastore emulator as described here and here. Unfortunately Google App Engine Python 3.7 Runtime does not provide the stub service. I have created a feature request for you. Please notice that there is no ETA for this type of requests nor a guarantee that it will be implemented.
Regarding your second question, I am not sure if the Datastore interface to ndb is supported by Google or if you are referring to a third party library. I have checked the current built-in third party libraries and I could not find an actual reference to it. For this, we would need more information and a link to the actual resources you are referring to.