Fwd: [GHDonline] 4 new items in Clinical Exchange

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Sandeep Kishore

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Feb 1, 2012, 8:50:34 AM2/1/12
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this is sort of neat -- people post difficult cases from rwanda and haiti via partners in health clinics and harvard doctors and students help troubleshoot -- 

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From: Aaron Beals <abe...@ghdonline.org>
Date: Wed, Feb 1, 2012 at 8:47 AM
Subject: Fwd: [GHDonline] 4 new items in Clinical Exchange
To: Product Team <pr...@ghdonline.org>, Sun Mi Yoo <sunm...@gmail.com>


We have our first multi-image case in Clinical Exchange!

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From: GHDonline <ghdo...@ghdonline.org>
Date: Tue, Jan 31, 2012 at 11:43 PM
Subject: [GHDonline] 4 new items in Clinical Exchange
To: Aaron Beals <abe...@ghdonline.org>


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        4 new items
 

Chylothorax?

I agree that it sounds like a chylothorax. If you could measure the triglyceride level, it could establish the diagnosis but you have already excluded pseudochylous effusion and it really does not sound like an empyema which can sometimes look milky. The absence of a large number of inflammatory cells and the relatively high glucose argues against that potential diagnosis.

The presentation with facial edema is interesting. Thrombosis of the superior vena cava or subclavian vein is a potential cause, especially in children, of a chylous effusion. Even heart failure and thoracic aortic aneurysm has been reported to cause it. Pleuritic pain is an unusual manifestation of chylous effusions; I wonder if that, in combination with a little weight loss, makes TB more likely in this case.

With TB and malignancy still in the differential diagnosis, it seems that the patient may benefit from a pleural biopsy to establish or exclude those potential causes. But his cardiac function and maybe great vessel patency should be investigated as well; sounds like he went into heart failure and had no relevant history. Very interesting case.


By Gerald Weinhouse on Jan. 31, 2012
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Amebic Renal Abscess?

Chief Complaint: Abdominal Pain

History of Present Illness: This is a 7 year old male admitted to Rwinkwavu Hospital Dec 13, 2011 for severe malnutrition (marasmus-type) accompanied with abdominal pain and vomiting for 1 month.

Pertinent Laboratory Values: HIV: Negative
Malaria Smear: Negative
Urinalysis: Negative
Stool Analysis: “Mobile Bacteria”

WBC: 8.25 x 10^9/L
Hgb: 11.2 g/dL
Plt: 680 x 10^9/L

Na: 139 mmol/L
K: 5.7 mmol/L
CL: 104 mmol/L
Ca: 1.16 mmol/L
TCO2: 28
Cr: 84 (normal)
Glucose: 137

SGOT: 19 IU/L
SGPT: 13 IU/L
Amylase: 314 IU/L
Lipase: No reagent

ESR: 70
CRP: Negative

Brief Hospital Course: This patient has been in the hospital for nearly two months now, so I will do my best to summarize their hospital course so far. Per protocol, the child was started on RUTF, as well as amoxicillin (1 week), folic acid, multivitamin, albendazole (3 days), and flagyl (2 weeks). He was also given intermittent pethidine and morphine injections for his abdominal pain, which speaks to its severity. While the child initially gained weight (12kg → 14kg over his first couple weeks), he continued to have intermittent abdominal pain and vomiting. Vital signs remained normal, and he has not had a fever during his entire hospital stay. Aside from a slight elevation of his amylase and some “mobile bacteria” seen on stool microscopy, his labs have been relatively normal (see most recent labs below) without any anemia or leukocytosis. A chest x-ray done on Jan 1, 2012 showed a question of reticular opacities, and an abdominal ultrasound done the same day showed a question of mesenteric lymphadenopathy, and so the patient was started presumptively on anti-TB therapy, with the thought that abdominal TB might be the cause of his pain. The patient continues to have daily severe abdominal pain and vomiting, despite TB therapy for nearly a month.

Specific Clinical Questions: We repeated the abdominal ultrasound today, and found two significant abnormalities. We are posting the images to get some help with the interpretation of the ultrasound findings. The first image is a transverse view of the liver taken in the epigastric region, which seems to show a large liver cyst, perhaps consistent with an amebic abscess (though odd the patient has not had fever). The second image is a longitdudinal view of the kidney taken at the left posterior axillary line. It seems to show a large cyst enveloping and compressing the kidney. Could this also be an amebic abscess? Would a CT abdomen be helpful in making a definitive diagnosis? It would be great to get further input on this challenging case.


By Adam Levine on Jan. 31, 2012
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Amebic Renal Abscess?

Here are the ultrasound images.


Attached resources: "Image 1.JPG" "Image 2.JPG"
By Adam Levine on Jan. 31, 2012
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Amebic Renal Abscess?

Hi Adam,
Ultrasound images are non-specific - ddx for this include abscess vs. complex cyst. There is debris within the cystic lesion. Any significant vascular flow within these lesions on Doppler? (to make sure it is not a solid lesion).

CT with intravenous contrast with delayed phases would help but but still may not be definitive. Aspiration / sampling of fluid would still be most definitive but CT can help localize/characterize/plan for any intervention.

best regards,
Garry

International Radiology Exchange (iRadX.org)
MGH Radiology
gc...@partners.org


By Garry Choy MD on Jan. 31, 2012
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Aaron C. Beals 
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--
Sandeep P. Kishore, Ph.D.
Department of Global Health & Social Medicine, Harvard Medical School
The Global Health Delivery Project at Harvard University
Co-Chair, Young Professionals Chronic Disease Network

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Maryam Shafaee

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Feb 1, 2012, 8:56:50 AM2/1/12
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This is really wonderful. 

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evance mmbando

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Feb 9, 2012, 2:40:32 AM2/9/12
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Amazing.!!!


From: Maryam Shafaee <marys...@gmail.com>
To: "globa...@googlegroups.com" <globa...@googlegroups.com>
Sent: Wednesday, 1 February 2012, 16:56
Subject: Re: [GHDonline] 4 new items in Clinical Exchange
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