Dj Azer
Jason
Azers bore a resemblance to dwarves, but with brass-colored skin and hair, their hair and beards composed of flames. Azer bodies were so hot that their weapons conducted heat, so much so that any creature within reach of an azer was injured by the intense heat.[7] Many azers wore kilts and apron-like garments made from beaten brass, bronze, or copper.[3][4][5]
Azer society was best described as communal, as every individual had a place in society and matters of the state were more important than that of the individual. Living within fortresses made of bronze on the Elemental Plane of Fire, azer nobles wielded absolute power.[3] Their outposts and cities were typically complexes of tower built from basalt, granite, or metal. Within these cities they grew strange trees with metallic bark and leaves.[4]
Azers were often slaves of fire giants and titans.[7] As for the other races, azers despised efreet, with whom they were often at war.[3] They maintained good relations with the yak folk found on the planes.[9]
Some sages claimed that dwarves were once all enslaved to giants and titans; modern dwarves descended from those who escaped slavery, while azers were the descendants of those who'd remained enslaved and were unable to escape their captors. Exposure to the Plane of Fire produced their unique fire qualities.[2]
The azers had once been allies of the efreet, and even helped build the City of Brass. When construction was finished, the efreet betrayed the azers, trying to enslave them to prevent their knowledge of the city's secrets from spreading. Since then, the fact that the azers knew secret ways into the city had prevented the efreet from unleashing an all-out conflict, so that only skirmishes between them happened.[1]
At some point, the archmage Trobriand summoned five azers to work for him on his layer of Trobriand's Graveyard in Undermountain. Later, the gnome Zox Clammersham was able to trick them into serving him, claiming to be Trobriand's apprentice.[11]
Azercabtagene zapreleucel (azer-cel; PBCAR0191 )is an investigational anti-CD19 allogeneic CAR T candidate being evaluated in a Phase 1/2a clinical trial of adult subjects with relapsed or refractory (R/R) non-Hodgkin lymphoma. This study is a multicenter, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study. Made from donor-derived T cells modified using our ARCUS genome editing technology, azer-cel recognizes the well characterized tumor cell surface protein CD19, an important and validated target in several B-cell cancers and is designed to avoid graft-versus-host disease, a significant complication associated with donor-derived, cell-based therapies. All subjects who receive a dose of azer-cel will be followed in a separate long-term follow-up study for 15 years after exiting this study. We have received orphan drug designation for azer-cel from the U.S. Food and Drug Administration for the treatment of ALL and MCL, as well as Fast Track Designation for azer-cel for the treatment of B-ALL.
PBCAR19B is a next-generation, anti-CD19 immune-evading stealth cell candidate being evaluated in a Phase 1 study of adult subjects with relapsed/refractory non-Hodgkin lymphoma. This study is a nonrandomized, open-label, single-dose, dose-escalation and dose-expansion study. PBCAR19B is designed to improve the expansion and persistence of allogeneic CAR T cells following infusion by reducing rejection by T cells and natural killer (NK) cells. In addition to the CAR gene, the PBCAR19B stealth cell vector carries a short hairpin RNA that suppresses expression of beta-2 microglobulin, a component of Class I Major Histocompatibility Complex (MHC) molecules found on the cell surface. Reducing or knocking-down Class I MHC expression on allogeneic CAR T cells has been shown to reduce CAR T cell killing by cytotoxic T cells. The PBCAR19B vector also carries an HLA-E gene intended to reduce rejection of CAR T cells by NK cells that can be stimulated as a result of reduced MHC molecule expression on the cell surface.
Evronia has a diversified portfolio of working in private and third sector technological organisations, as well as teaching and research in Higher Education in the UK (UCL, and Royal Holloway University of London).
Evronia is currently part of the Data, Organisations and Society research cluster in the Centre for Business in Society (CBiS). She is Ethics Lead for CBiS and takes part in DBA and PGR supervision. She also supports the enriching of teaching with research through designing research focused case studies and guest lectures. She has won the competitive 2021-2022 Trailblazer Studentship by Coventry University to support early-career researchers to recruit a funded PhD student and lead a supervisory team, for the topic "Technology-Enabled Monitoring, Privacy and Datafication of Home Working in the UK".
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