Mean expression calculations

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Will Lyon

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Apr 14, 2014, 3:29:10 PM4/14/14
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Hello,

When I select the mean expression header to display the expression levels for each gene on the heatmap, what unit is the expression displayed in?

Thank you

Michael P Schroeder

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Apr 15, 2014, 3:56:31 AM4/15/14
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Hi Will

I am not quite sure what data you are working with. Are you talking about a heatmap available gitools.org/datasets? Also, if are you adding a header by aggregating values from a heatmap? 

Anyhow, the TCGA data heatmaps at gitools.org/datsets contain expression values that are normalized and centered so that 0 means normal expression, positive values is high expression and negative values are low expression. The high and low are relative to the other samples of the cohort. Adding a mean expression to rows or columns does not change the scale or unit.

Hope this helps,

Michael



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