Fwd: Mixed Models: How to Effectively Account for Inbreeding and Population Structure in GWAS

[Gregor GORJANC]

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From: Jessica Vionas <vio...@goldenhelix.com>
Date: 22 May 2013 14:03
Subject: Mixed Models: How to Effectively Account for Inbreeding and Population Structure in GWAS
To: gregor....@bf.uni-lj.si

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	Mixed Models: How to Effectively Account for Inbreeding and Population Structure in GWAS Greta Linse Peterson, Senior Statistician Wednesday, June 5th at 12:00 pm EDT Reserve your seat now! www2.gotomeeting.com/register/792047594
Population structure and inbreeding can confound results from a standard genome-wide association test. Accounting for the random effect of relatedness can lead to lower false discovery rates and identify the causative markers without over-correcting and dampening the true signal. This presentation will review four different methods of analyzing genotype data while accounting for random effects of relatedness. Methods include PCA analysis with Linear Regression, GBLUP, EMMAX, and MLMM. Comparisons will be made using data from the Sheep HapMap project and a simulated phenotype. After presenting the various methods, we will discuss how these results can be obtained using Golden Helix SNP & Variation Suite (SVS) software and how SVS can be used to compare and contrast the results. Register at: www2.gotomeeting.com/register/792047594 Hope to see you there! Jessica Vionas Marketing Coordinator 406-585-8137 Golden Helix Webcast JUN 5   Wed, June 5 12:00 pm EDT Questions 888-589-4629 406-585-8137 in...@goldenhelix.com

About Golden Helix Founded in 1998, Golden Helix is known for helping genetic research groups working with large-scale DNA-sequencing or microarray data overcome the frustration and challenges of bioinformatic roadblocks: delayed projects, lack of quality findings, and low productivity. By empowering researchers with highly effective software tools, world-class support, and an array of complementary analytic services, we refute the notion that analysis has to be difficult or time consuming. Golden Helix's flagship software product, SNP & Variation Suite (SVS), is an integrated collection of powerful data management, quality assurance, visualization, and tertiary analysis tools for genetic data. SVS is delivered in a user-friendly, scalable platform and is supported by a team of highly trained bioinformaticians, statistical geneticists, and computer scientists that together make advanced statistical and bioinformatic methods accessible to scientists of all levels.

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With regards!

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University of Ljubljana     Asst. Prof. Gregor Gorjanc, PhD
Biotechnical Faculty        www: http://sites.google.com/site/gregorgorjanc
Animal Science Department   blog: http://ggorjan.blogspot.com
Groblje 3                   mail: gregor.gorjanc <at> bf.uni-lj.si
SI-1230 Domzale             fax: +386 (0)1 724 10 04
Slovenia, Europe            tel: +386 (0)1 320 38 61
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Lep pozdrav!

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Univerza v Ljubljani        doc. dr. Gregor Gorjanc
Biotehniška Fakulteta       www: http://sites.google.com/site/gregorgorjanc
Oddelek za zootehniko       blog: http://ggorjan.blogspot.com
Groblje 3                   mail: gregor.gorjanc <at> bf.uni-lj.si
1230 Domžale                fax: +386 (0)1 724 10 05
Slovenija                   tel: +386 (0)1 320 38 61
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