If you are referring to atmospheric pressure, on the outside of a vacuum vessel, I can tell you that the vessel must be tremendously strong. The larger the vessel, the more-drastic the results.
Memorize two rules, for any sphere:
• the surface-area goes up as the square² of the radius
• the volume goes up as the cube³ of the radius
For example, as the radius of a spherical vacuum-vessel doubles, the surface area quadruples. That's why you only (commonly) see small vacuum vessels. The large vacuum vessels, used for vacuum-drying biological materials, have VERY thick walls of welded steel.
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Note that Buckminster Fuller postulated a lightweight geodesic dome/sphere, containing heated air (solar or urban sourced,) which would be self-supporting, or would float like a hot-air balloon. So, you don't, necessarily, need a vacuum. Less-dense gas may, perhaps, be sufficient for your goal.
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The "vacuum bouyant" concept is not new. Various scientists, for decades, have postulated such, but found no solution, due to the non-existence of structural material that is lightweight, yet, strong enough. Some scientists think that, perhaps, a future form of carbon nanotube-weave material may someday be developed, which would meet the strength requirements.
-Taff