Minimum sample size, SNP-h2 and rG?

[isabell...@gmail.com]

Hi!  

I am wondering if there is a lower bound / recommended minimum N, SNP-h2 and cross-traits LDSC rG for the GWAS summary stats to be used in Genomic-SEM?

Thanks

Isabell 

[Michel Nivard]

Hi Isabell,

No there is not hard limit. I prefer the h2 and rg to have a Z statistics of >5 when you run them trough clasic LDSC, but > 2.5 may still work. Obv isf the h2 is 0 or negative or other silly values its game over.

Best,

Michel

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[isabell...@gmail.com]

Great, thanks for quick reply!