GWAS-by-subtraction sumstats genetic correlation

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Marta Ribases

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May 24, 2024, 7:41:14 AMMay 24

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Hi,

I run GWAS-by-subtraction and apparently it worked well. However, what I found unexpected is that the genetic correlation between the resulting sumstats was strongly negative (rg=-0.38, P=1.0e-31). Given that the covariance between both latent factors was set at 0, I just wonder if this could be an artifact of the method.

Many thanks in advance,