Stem Cell Patent News (1/3/10)

[Sciclips]

US patents issued (12/28/09)

1. Differentiation of a stem cell into a cardiomyocyte using soluble
form of the Cripto protein
2. Myocardial differentiation of human blastocyst-derived stem cells
(hBS cells) under feeder free conditions
3. Enrichment of breast stem cells using CD24 and CD49f antibodies

US Patent applications (12/31/09)

1. Embryotoxicity/teratogenicity screening using secreted reporter
proteins in stem cells
2. Cartilage formation from mesenchymal stem cells using reduced
pressure treatment
3. Method for differentiation of single pluripotent stem cells
4. GSK-3B enzyme inhibitors for the differentiation and proliferation
of human embryonic stem cells
5. Method for maintaining hES cells in a non-differentiated state by
inhibitor of cell development (TGFP) and anti-inhibitor of cell
proliferation (anti-TGF beta)
6. Method for inducing differentiation of cardiomyocytes from
pluripotent stem cells by activation of the canonical Wnt signaling
pathway
7. Preparation and applications of multicellular spheroids derived
directly from biological tissue /bodily fluid stem cells or cancer
stem cells
8. Drug screening using islet cells and islet cell progenitors derived
from human embryonic stem cells
9. Detection and isolation of leukemia stem cells using self-renewal
associated signature protein EPHA7
10. Self-renewal signature gene products as targets for the treatment
of leukemia or cancer cells
11. Method of treating new onset type 1 diabetes (T1D) using
mesenchymal stem cells
12. Biomarkers for the detection of differentiation of hematopoietic
stem cells into megakaryocytes and platelets
13. Method for the differentiation of CD34+ hematopoietic stem cells
into megakaryocytes and platelets
14. Neuronal progenitor cells from marrow adherent stem cells using
inhibitor of STAT1 or STAT3
15. Induced pluripotent stem cells for identifying drug candidates
16. Mesenchymal stem cells for treating degenerative disc disease
17. Neural stem cells from soft tissue of tooth or wisdom tooth

WO (PCT) applications (12/30/09)

1. Compounds for the inhibition of Rho kinase in stem cells and
therapeutic applications
2. Induced pluripotent stem cells from mesoangioblast-like cells
3. Human skin substitute from human keratinocytes derived stem cells
4. Use of specific oxygen concentrations for the differentiation of
non-ES stem cells to functional blood vessels
5. A compound from a naturally occurring fraction of Enamel Matrix
Derivatives (EMD) for regulating mesenchymal stem cell proliferation
and differentiation
6. Peptide analogs of FGF for stimulating hematopoietic/
gastrointestinal stem cell proliferation

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