The problems of using GeneMANIA database

[廖伟]

Dear GeneMANIA team,

I am a graduate student of the Neuroscience Research Center in Chongqing Medical University, named Wei Liao. Now I would like to use GeneMANIA database for interaction network analysis, and to download the interaction network data for further research. However, we encountered some problems when using the GeneMANIA database.

Firstly, we don't know what the weight score represents, we guess that whether it is represents the confidence (the strength of the data support), for example: If the weight score of the interaction between the two genes is 0.8, then the confidence of the interaction between the two genes is 80%. Could you please tell me the meaning of the weight score?

Secondly, when we use the data downloaded from the STRING database, we usually use 0.4 as the minimum required interaction score. How much weight score should be taken when processing data downloaded from the GeneMANIA database as compared to the interaction score of 0.4 in the STRING database?

I am looking forward to your reply. Thank you very much.

 

Best wishes,

Wei Liao

Institute of Neuroscience

Chongqing Medical University

No. 1 Yixue Road, Yuzhong District, Chongqing 400016, China

E-mail: 20181...@stu.cqmu.edu.cn

 

[廖伟]

Dear GeneMANIA team,

I am a graduate student  the Neuroscience Research Center in Chongqing Medical University, named Wei Liao.Now I would like to use GeneMANIA database for interaction network analysis, and to download the interaction network data for further research. However, we encountered some problems when using the GeneMANIA database.