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Current Harvard Undergraduates: contact Kate Penner Undergraduate Science Research Advisor, for advice on applying for research positions. If you find a position below that looks interesting, please contact the lab directly.
Undergraduate Research Opportunity, Dr. Rashidian, Department of Cancer Immunology and Virology, Radiology, Dana-Farber Cancer Institute/Harvard Medical School, Posted April 2024.
Multiple projects on leveraging machine learning for biomedical applications, Marks Lab, Harvard Medical School, Systems Biology, Broad Institute, Posted April 18, 2024.
Undergraduate Research Opportunity, Generating a Biobank of Genotyped Human Blood Samples for Assays of Parasite Infection, Immunology & Infectious Diseases, Harvard Chan School of Public Health (HSPH), Posted March 12, 2024.
Undergraduate Research Opportunity, An Augmented Reality (AR) Smart Decisions Support System to Advance Trauma Care at the Point of Injury, Emergency Medicine, MGH, Harvard Medical School, Posted March 12, 2024.
Undergraduate Research Opportunity, Multiple projects on medical image segmentation and brain connectivity analysis, Radiology, Martinos Center for Biomedical Imaging, MGH, Harvard Medical School, Posted March 12, 2024.
Undergraduate Research Opportunity, Chemical Biology Approaches to Study Glycoproteins in Bleeding and Clotting Disorders, Departments of Medicine and Hematology, Brigham and Women's Hospital, Harvard Medical School, Posted March 12, 2024.
Undergrad Research Opportunity, Protein Engineering and Synthetic Biology, Church Lab, Harvard Medical School
Research Opportunity, Multiple projects on use of CRISPR base editing to understand complex genetic disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Posted August 26, 2023.
Research Opportunity, Medicinal Plant Genomics Project, Department of Organismic and Evolutionary Biology, Harvard Herbaria, Harvard Faculty of Arts and Sciences, Posted August 25, 2023.
Research Opportunity, Multiple Projects involving Magnetic Resonance Imaging of Brain Vascular Physiology in Aging and Alzheimer's Disease, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Posted August 25, 2023.
Research Opportunity, Mechanical Forces in Brain Cancer, Edwin L. Steele Laboratories, Department of Radiation Oncology, MGH, Harvard Medical School, Posted August 25, 2023.
Research Opportunity, Functional genetics of blood coagulation, Harvard-MIT Division of Health, Sciences, and Technology, Beth Israel Deaconess Medical Center, Harvard Medical School, Posted August 23, 2023.
Research Opportunity, Multiple Projects on Developing Computer Vision and Deep Learning Methods for Image-guided Medical Interventions, Surgical Planning Lab, Radiology/Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Posted August 23, 2023.
Research Opportunity, Multiple projects on Exploring Adipose Tissue Dynamics: Unraveling Energy Balance and Pathogenic Associations, Joslin Diabetes Center, Harvard Medical School, Posted August 14, 2023.
The Postpartum Traumatic Stress Disorders Research Program and the Dekel lab ( ) at the Department of Psychiatry of Massachusetts General Hospital studies maternal psychopathology following the singular event of childbirth. Our aim is to develop empirically based therapies and accurate screening tools for early identification of women at risk for postpartum mental illness to lower the odds of maternal psychiatric morbidity. We are seeking a clinical research coordinator to take part in NIH-funded clinical and translational research investigations concerning maternal psychopathology and infant development as well as other studies focused on global maternal mental health performed with teams outside the US.
Students are welcome to contact Dr. Sharon Dekel (sde...@mgh.havard.edu) to learn about this job and other research opportunities. Option for full- or part-time commitment.
Undergraduate Research Opportunity, Dr. Rashidian, Department of Cancer Immunology and Virology, Radiology, Dana-Farber Cancer Institute/Harvard Medical School
Contact information: Mohammad Rashidian, Ph.D.
Assistant Professor, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
Assistant Professor of Radiology, Harvard Medical School
-farber.org/
Project description and duties: Developing novel immunotherapies to treat cancer
Immunotherapy has revolutionized cancer treatment. However, a significant proportion of patients still do not respond effectively. In our lab, we delve into cancer immunology, leveraging our expertise in protein engineering, molecular biology, and immunology. Our primary focus is unraveling the intricate mechanisms underlying the dynamic changes in the tumor microenvironment triggered by cancer immunotherapies. Through our research, we aim to develop innovative diagnostic, prognostic, and therapeutic tools that enable precise detection, characterization, treatment, and prevention of cancer.
Enhancing the activity and persistence of CAR T cells is a key area of investigation in our lab. CAR T cells have revolutionized the treatment of various blood-borne malignancies. However, the duration of response often falls short, leading to patient relapse. To address this challenge, we are developing novel immunotherapeutics to drive CAR T cells toward adopting a memory phenotype. This approach holds great potential in prolonging the response duration and overcoming relapse.
Skills required: Students with basic biology lab skillsets are encouraged to apply. Students will have the opportunity to work with senior scientists in the lab who will provide training in various lab techniques.
Learning outcomes: research skills such as study design, data analysis methods, presentations, scientific writing, and attending seminars/conferences at Dana-Faber/Harvard, as well as lab skillsets such as protein engineering, protein expression, and purification, ELISA analysis, generating stable cell lines, cell culture, running SDS-PAGE, mass-spectrometry, western blot analyses, protein labeling, and working with
instruments such as FPLC, LC-MS, microscopy and flow cytometry.
Length of the project: summer 2024, however, students can stay in the lab until they perform their thesis.
Mentoring: senior graduate students and postdocs in the lab will be mentoring students. The PI will have
regular weekly meetings with students as well.
Student stipend: positions are volunteer positions, however the PI will work with students to apply for available fellowship programs (HCRP, PRISE, etc.).
Application information: motivated students should contact Dr. Rashidian at mohammad_...@dfci.harvard.edu
Multiple projects on Mechanistic studies of muscle hypertrophy and atrophy, Dept of Medicine, MGH, Harvard Medical School, Posted April 2024.
PI: Gregory Wyant
Charlestown, in-person opportunity
The laboratory is dedicated to pursuing a cellular and molecular understanding of how physiological cues, such as oxygen, nutrients, mechanical, or electrical signals regulate tissue physiology and function, with special reference to heart and skeletal muscle. We have a deep interest in understanding the pathophysiological consequences of disruption of any of these signals, such as in the setting of ischemic injury, starvation, or denervation, and development of novel therapeutic approaches. We are particularly interested in organelle metabolism in relation to these tissues and the development of novel tools to isolate and study compartmentalized metabolism in the in vivo context.
Who this project might be a good fit for, in terms of interests and/or goals: Those interested in tissue physiology, cell biology, biochemistry, genetics. Those interested in basic and translational science. Interest in graduate or medical school.
Requirements: Must be able to travel to Charlestown Navy Yard MGH campus, otherwise No previous research experience is required, though previous laboratory experience is a plus. We will teach you all the skills you need. Students are welcome to use this research opportunity for concentration credit. The PI will support students in applying for undergraduate research fellowships such as HCRP.
This project/lab is thesis-friendly.
If interested, please contact: Gregory Wyant, gwy...@mgh.harvard.edu
Undergraduate Opportunity, Ramanathan Lab, Posted April 6, 2024.
The Ramanathan Lab has a position for motivated undergraduate students to study the mechanisms underlying the maintenance and differentiation of multipotent stem cells that drive the elongation of the human embryo using an in vitro organoid system. In this project, you will help elucidate the feedback mechanisms that govern the proper proportions of these neural progenitors (Nps), and mesodermal progenitors (Mps) as the organoids develop and elongate to generate the spinal cord and flanking muscles. You will work closely with a postdoctoral fellow, Professor Ramanathan, and other lab members to apply cutting-edge high-throughput bioengineering, sequencing stem cell biology and perturbation techniques.
This is an excellent opportunity to gain hands-on experience conducting developmental biology research using state-of-the-art methods.Ideally we are looking for students who have research experience and are looking for opportunities for a senior thesis in the future. Please email Sharad (sha...@post.harvard.edu) and Alon ( aloncha...@fas.harvard.edu ) if you are interested.
Multiple Projects on Clinical Computational Neuroimaging, Radiology, Martinos Center for Biomedical Imaging, Mass General Hospital, Harvard Medical School, Posted March 19, 2024.
PI: Ona Wu, ccni.mgh.harvard.edu
Charlestown campus, Hybrid opportunity
We are a team of interdisciplinary individuals interested in data science and clinical research. Our research activities focus on developing methods to improve the diagnosis, prognosis, and management of patients with brain injury as a result of stroke, cardiac arrest, or trauma. We use state-of-the-art MRI acquisition and analysis techniques and combine imaging with clinical data via machine learning algorithms to create quantitative biomarkers that can be used to monitor disease progression or recovery. The following are examples of our research topics. We used an imaging-based model in a prospective clinical trial to triage patients with unwitnessed acute ischemic stroke for thrombolytic therapy, offering treatment options to patients for whom none had existed. We developed machine learning methods to predict tissue and clinical outcomes after acute ischemic stroke and to evaluate the therapeutic efficacy of novel stroke treatments. For comatose cardiac arrest patients, we applied imaging to predict long-term neurological outcomes by investigating changes in post-arrest structural and functional brain connectivity. We developed algorithms to combine structural and functional MRI to evaluate the sequelae of post-concussive mild traumatic brain injury. We developed methods to measure cerebral blood flow, cerebral blood volume, and blood-brain barrier permeability calculated from dynamic-susceptibility contrast MRI.