Hi William,
As per the error message, it appears that you have setup some firewall rules, at instance level, that is blocking outgoing UDP packets to 169.254.XXX.XXX if the size is bigger than 300 bytes.
If the IP address is the 169.254.169.254, that is the metadata server, I'll recommend reviewing your instance firewalls and consider allowing traffic for it, so your instance can reach this server.