For this week's journal club, Laetitial Jubin will present her work with Peter Latham.
Title: At last -- a use for all those inhibitory neurons that are clogging up anatomy textbooks
Abstract: The neocortex is composed of two primary types of neurons -- excitatory and inhibitory. Models composed of these two types have been successful in explaining many commonly observed phenomena (e.g. low firing rates, oscillations, up/down states, and asynchronous firing). However, there are in fact many types of inhibitory neurons, and the different types have different connectivity patterns. We found that the main effect of these different subtypes is to allow circuits to switch from a state where all the populations are on, to another state where one or more inhibitory population is off, just by modifying the input to the circuit. Such switches are important, as they have the potential to mediate different behavior.