[TNJC] Neuro Journal Club this week (14/2, 2pm, Friday)
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Ben Dongsung Huh
Feb 12, 2014, 4:25:48 PM2/12/14
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Dear all,
In this week's TNJC, Marius will present the following paper.
https://www.cell.com/neuron/abstract/S0896-6273(13)00751-4
Optogenetic Activation of an Inhibitory Network Enhances Feedforward Functional Connectivity in Auditory Cortex
Liberty S. Hamilton, Jascha Sohl-Dickstein, Alexander G. Huth, Vanessa M. Carels, Karl Deisseroth,
and Shaowen Bao
SUMMARY
The mammalian neocortex is a highly interconnected network of different types of neurons organized into both layers and columns. Overlaid on this struc- tural organization is a pattern of functional connec- tivity that can be rapidly and flexibly altered during behavior. Parvalbumin-positive (PV+) inhibitory neu- rons, which are implicated in cortical oscillations and can change neuronal selectivity, may play a pivotal role in these dynamic changes. We found that opto- genetic activation of PV+ neurons in the auditory cor- tex enhanced feedforward functional connectivity in the putative thalamorecipient circuit and in cortical columnar circuits. In contrast, stimulation of PV+ neurons induced no change in connectivity between sites in the same layers. The activity of PV+ neurons may thus serve as a gating mechanism to enhance feedforward, but not lateral or feedback, information flow in cortical circuits. Functionally, it may preferen- tially enhance the contribution of bottom-up sensory inputs to perception.
See you then!
Next presenter list:
Maneesh 21/2/2014
Cosyne Week 28/2/2014
Interview Week 3/7/2012
Cosyne Wrapup 3/14/2012
TNJC website: http://www.gatsby.ucl.ac.uk/tnjc/
Ben Dongsung Huh
Gatsby Computational Neuroscience Unit
In this week's TNJC, Marius will present the following paper.
https://www.cell.com/neuron/abstract/S0896-6273(13)00751-4
Optogenetic Activation of an Inhibitory Network Enhances Feedforward Functional Connectivity in Auditory Cortex
Liberty S. Hamilton, Jascha Sohl-Dickstein, Alexander G. Huth, Vanessa M. Carels, Karl Deisseroth,
and Shaowen Bao
SUMMARY
The mammalian neocortex is a highly interconnected network of different types of neurons organized into both layers and columns. Overlaid on this struc- tural organization is a pattern of functional connec- tivity that can be rapidly and flexibly altered during behavior. Parvalbumin-positive (PV+) inhibitory neu- rons, which are implicated in cortical oscillations and can change neuronal selectivity, may play a pivotal role in these dynamic changes. We found that opto- genetic activation of PV+ neurons in the auditory cor- tex enhanced feedforward functional connectivity in the putative thalamorecipient circuit and in cortical columnar circuits. In contrast, stimulation of PV+ neurons induced no change in connectivity between sites in the same layers. The activity of PV+ neurons may thus serve as a gating mechanism to enhance feedforward, but not lateral or feedback, information flow in cortical circuits. Functionally, it may preferen- tially enhance the contribution of bottom-up sensory inputs to perception.
See you then!
Next presenter list:
Maneesh 21/2/2014
Cosyne Week 28/2/2014
Interview Week 3/7/2012
Cosyne Wrapup 3/14/2012
TNJC website: http://www.gatsby.ucl.ac.uk/tnjc/
Ben Dongsung Huh
Gatsby Computational Neuroscience Unit
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