[TNJC] Neuro Journal Club this week (15/4, 2pm, Tuesday)

[Ben Dongsung Huh]

Dear all, 

For this week's TNJC, Huyen Nguyen will present her research.

Title: An overview of axon guidance
Huyen Nguyen, University of Queensland (Australia)

Abstract: Chemotaxis (detecting and following chemical gradients) plays a crucial role in the function of many biological systems. In particular, gradient following by neuronal growth cones is important for the correct wiring of the nervous system. However, the mechanisms axons use to detect gradients are largely unknown. In this talk, I will present a Bayesian "ideal observer" analysis of gradient detection by axons, based on the hypothesis that a principal constraint on gradient detection is intrinsic receptor binding noise. From this model, we derived an equation predicting how the degree of response of an axon to a gradient should vary with gradient steepness and absolute concentration. I will introduce a new microfluidic method that allows much finer spatial and temporal control over the gradient to further study other aspects of axon guidance.  

Easter Week     22/4/2014

Tom                 29/4/2014

Gergo               06/5/2014

Joana               13/5/2014

Ben Dongsung Huh
Gatsby Computational Neuroscience Unit