To get Gaphor running on OS X, some more stuff is required. You can build it all through Homebrew <https://github.com/amolenaar/homebrew> (pygtk branch) or MacPorts <http://www.macports.org/>. Yuo'll need to build both Pycairo and PyGTK.
The much simpler solution is to download and run Gaphor from the prepared DMG at http://pypi.python.org/pypi/gaphor/. I prepared this DMG on Snow Leopard. You still need to have X11 installed (it's on your installation dvd if not installed already).
Hope this helps,
Regards,
Arjan
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Why not use the prebuilt app? Easy_install is not making those.