ORC or Origin Recognition Complex
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Gainover
Oct 3, 2008, 7:51:07 AM10/3/08
to 生物资料论坛 BIOLOGY
ORC or Origin Recognition Complex is a multisubunit complex (6
subunits) existing in the replication procedure of DNA. It marks the
replication origin by binding to and marking ori sequences in all
eukaryotes in an ATP-dependent manner. During the G1 phase of the cell
cycle, when CDK levels are low, ORC recruits cdc6 and cdt1 proteins.
Cdc6 and cdt1 block DNA helicase. During the transition to S phase CDK
levels increase, CDK phosphorylates cdc6 and cdt1, and they are
removed. Now DNA helicase can open the double stranded DNA and
replication begins. DDK also participates in ORC activation and
triggers the transition into DNA replication.
subunits) existing in the replication procedure of DNA. It marks the
replication origin by binding to and marking ori sequences in all
eukaryotes in an ATP-dependent manner. During the G1 phase of the cell
cycle, when CDK levels are low, ORC recruits cdc6 and cdt1 proteins.
Cdc6 and cdt1 block DNA helicase. During the transition to S phase CDK
levels increase, CDK phosphorylates cdc6 and cdt1, and they are
removed. Now DNA helicase can open the double stranded DNA and
replication begins. DDK also participates in ORC activation and
triggers the transition into DNA replication.
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