Insulator (genetics)

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Insulator (genetics)
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For electrical insulator, see Insulator (Electrical).
For other uses, see insulation.
An insulator is a genetic boundary element that plays two distinct
roles in gene expression, either as an enhancer-blocking element, or
more rarely as a barrier against condensed chromatin proteins
spreading onto active chromatin. The need for them arises where two
adjacent genes on a chromosome have very different transcription
patterns, and it is critical that the inducing or repressing
mechanisms of one do not interfere with the neighbouring gene.[1]


[edit] References
^ Burgess-Beusse, B, et al. (Dec 2002). "The insulation of genes from
external enhancers and silencing chromatin". Proc. Natl Acad. Sci. USA
9 (Suppl 4): 16433-16437. doi:10.1073/pnas.162342499.
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