comments after first use

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dwag...@stanford.edu

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Sep 1, 2017, 5:18:36 PM9/1/17
to FUMA GWAS users
Awesome tool! Here were my thoughts after first testing it.

  1. what genes/snps associated with a pathway i.e. magma
  2. mapped genes table sorting on eqtmapminp doesn't sort using scientific notation
  3. nice to have genes in the default locus plots before adding annotation
  4. gwas catalog intersection using snps with lower pvalues not just top snps
  5. gwas catalog intersection using LD not just direct hits in case we didnt impute or have different platforms
  6. lower default minimum than 1e-5. the enrichments look nicer if the variants are curated a bit. in fact it would be nice to have some template snp curations for snps that are more likely to be true i.e. higher maf, eqtl, motif intersection or genic snps
  7. new query remembers last settings or can use previous run's settings. usually i just want to tweak one parameter
  8. direct gene2func queries (useful for sequencing and cnv results) should persist in "my queries"
  9. eqtl tissue enrichment scores
  10. support for vcf input for sequencing experiments

Kyoko Watanabe

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Sep 3, 2017, 3:46:18 AM9/3/17
to FUMA GWAS users
Hi there,

Thank you for your suggestions!!
I will consider them for the next version and will let you know which can fit in FUMA and which cannot.

Best,
Kyoko
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