FUMA an error occurred

[Esh]

Hi Kyoko,

Thanks for the amazing platform and I am really  happy to use this user friendly web application. Earlier I uploaded some meta-analysis based on P-value results which did using METAL and FUMA was functioning very well ( Job IDs  17481 and 17025). This time I did the same meta-analysis using METAL but  based on effect estimates and uploaded to FUMA but I get error results (  Job ID 21265 1. invalid input parameters or 2. columns are mistakenly labelled wrong.and Job ID 21269 - No significant SNPs were identified). However, am pretty sure for the 17025 ( previous job)  had many GWAS significant hits and for the same Job ID 21269  give an error. 

Also, Job ID 21265 columns are like this. 

MarkerName Allele1 Allele2 Effect StdErr P-value Direction HetISq HetChiSq HetDf HetPVal

rs2326918 a g 0.0118 0.0007 2.306e-60 -+- 0.0 1.920 2 0.3829

rs66941928 t c -0.0276 0.0006 1.09e-397 --- 0.0 0.775 2 0.6787

rs6039163 t c 0.1698 0.4254 0.6898 +?? 0.0 0.000 0 1

rs6977693 t c 0.0167 0.0007 3.05e-114 -++ 0.0 1.321 2 0.5165

I cannot find what cause these error??

Thanks in advance.

Esh

[Kyoko Watanabe]

Hi Esh,

Thank you for using FUMA and I'm sorry about the inconvenience.

I do not have access to user's input file but judging from manhattan plot, is your P-value correct?

For example there is a SNP with P-value like 1e-11854.

Could you maybe attach first 100 lines of your input file (or if possible chr 1)? Please send by personal email.

Best,
Kyoko