Quanta Free Download
Raul Herrera
In physics, a quantum (pl.: quanta) is the minimum amount of any physical entity (physical property) involved in an interaction. Quantum is a discrete quantity of energy proportional in magnitude to the frequency of the radiation it represents. The fundamental notion that a property can be "quantized" is referred to as "the hypothesis of quantization".[1] This means that the magnitude of the physical property can take on only discrete values consisting of integer multiples of one quantum. For example, a photon is a single quantum of light of a specific frequency (or of any other form of electromagnetic radiation). Similarly, the energy of an electron bound within an atom is quantized and can exist only in certain discrete values.[2] Atoms and matter in general are stable because electrons can exist only at discrete energy levels within an atom. Quantization is one of the foundations of the much broader physics of quantum mechanics. Quantization of energy and its influence on how energy and matter interact (quantum electrodynamics) is part of the fundamental framework for understanding and describing nature.
The word quantum is the neuter singular of the Latin interrogative adjective quantus, meaning "how much". "Quanta", the neuter plural, short for "quanta of electricity" (electrons), was used in a 1902 article on the photoelectric effect by Philipp Lenard, who credited Hermann von Helmholtz for using the word in the area of electricity. However, the word quantum in general was well known before 1900,[3] e.g. quantum was used in E. A. Poe's Loss of Breath. It was often used by physicians, such as in the term quantum satis, "the amount which is enough". Both Helmholtz and Julius von Mayer were physicians as well as physicists. Helmholtz used quantum with reference to heat in his article[4] on Mayer's work, and the word quantum can be found in the formulation of the first law of thermodynamics by Mayer in his letter[5] dated July 24, 1841.
In 1901, Max Planck used quanta to mean "quanta of matter and electricity",[6] gas, and heat.[7] In 1905, in response to Planck's work and the experimental work of Lenard (who explained his results by using the term quanta of electricity), Albert Einstein suggested that radiation existed in spatially localized packets which he called "quanta of light" ("Lichtquanta").[8]
While quantization was first discovered in electromagnetic radiation, it describes a fundamental aspect of energy not just restricted to photons.[12]In the attempt to bring theory into agreement with experiment, Max Planck postulated that electromagnetic energy is absorbed or emitted in discrete packets, or quanta.[13]
KRAS mutations and amplifications are a driver in nearly one-quarter of all cancers. We are developing allosteric small molecules to target previously undruggable RAS mutations, such as KRASG12D and KRASG12V, in difficult to treat cancers, including pancreatic, colorectal, lung and endometrial cancer types. KRAS inhibitors have been developed to target the KRASG12C mutation, but these therapies are limited to only around ten percent of KRAS-driven cancers.
We are focused on modulation of RAS signaling at the cell membrane to broaden the scope of treatable RAS-driven cancers. We are applying deep biologic insight, unique protein conformation detection technology, sophisticated medicinal chemistry, and clinical development expertise to advance multiple, chemically distinct KRAS inhibitor programs with differentiated mechanisms of action. Our technology and capabilities are enabling the development of best-in-class, oral, small molecules with the potential to lead the next wave of innovation in KRAS therapy.
We are an experienced team of RAS biology leaders, innovative medicinal chemists, and clinical development experts. The Quanta team brings together a scientific foundation based on discovery research from RAS signaling pioneers with extensive oncology-focused small molecule translational and clinical development experience. Collectively, our leadership team has contributed to the discovery, development, approval, and launch of multiple biopharmaceutical medicines.
Perry became CEO of Quanta Therapeutics in June 2021 after having served as the founding Executive Chairman of the company during formation in his role as Executive Partner at Sofinnova Investments beginning in 2018. He is a physician scientist with extensive experience in drug discovery and development with particular interest in oncology. Perry is the former CEO of the Sanford Burnham Prebys Medical Discovery Institute (SBP). As CEO, he was responsible for all aspects of the organization including strategy, operations and performance. Prior to SBP, he held multiple senior leadership positions during his tenure at GlaxoSmithKline (GSK) including SVP of Science and Innovation, interim Chief Medical Officer, and Oncology Therapy Area Head. Responsibilities at GSK included all aspects of drug discovery, clinical development, risk/benefit and operations. Before GSK, Perry was the Divisional Vice President, Cancer Research then Oncology Clinical Development at Abbott Laboratories. Prior to industry he was the Lowe Foundation Professor at the University of Texas Southwestern Medical Center. Perry holds a BS from Stanford University, and MD/PhD from the Albert Einstein College of Medicine. He is also an independent Director of TEVA Pharmaceuticals, and chair of their science and technology committee.
Hong is Senior Vice President of Drug Discovery at Quanta Therapeutics. Before joining Quanta, Hong was Executive Director, Head of Early Discovery at Prelude Therapeutics, where she led the PRMT5 program that delivered clinical candidates PRT543 and PRT811 within a two-year period. Prior to Prelude, Hong held multiple leadership roles in medicinal chemistry and virtual drug discovery groups within the therapeutic areas of oncology, neuroscience and regenerative medicine during her 15-year tenure at GlaxoSmithKline. Hong holds a Ph.D. degree in Organic Chemistry from the Brandeis University and did her postdoctoral training under an NIH fellowship at Memorial Sloan-Kettering Cancer Center.
Juan is Senior Vice President of Chemistry at Quanta Therapeutics. Juan leads chemistry strategy and structural modeling for drug discovery. Before joining Quanta, Juan was Founding Scientist and VP of Drug Discovery at Prelude Therapeutics, an oncology start-up company in Delaware. Prior to Prelude, Juan worked for 27 years at GSK, where he was Head of Chemistry in the Cancer Epigenetics group. During his 30+ years in pharmaceutical research, Juan has managed the progression of several compounds into clinical studies in different therapeutic areas. Most notably Juan was one of the inventors of Promacta (eltrombopag), and he successfully led this first-in-class TPO Receptor agonist agent to the clinic. Juan holds a Ph.D. degree in Organic Chemistry from the University of Michigan and did postdoctoral research at Stanford University.
Derek Metzger is the SVP Corporate Strategy and Operations at Quanta. Derek has worked in oncology drug development for 15 years, most recently as the Executive Director of Strategy at Tempest Therapeutics. Prior to Quanta and Tempest, Derek worked at Aduro Biotech, and Onyx Pharmaceuticals and has held roles spanning many different functions, including finance, business development, strategic planning, program leadership, and commercial. Derek graduated from Brown University with a degree in Economics.
Mike Kramer, Vice President, Head of Scientific Operations at Quanta Therapeutics, has over 30 years of experience in pharmaceutical and biotechnology research and development, overseeing nonclinical development, CMC, regulatory, and project management activities. Prior to joining Quanta, Mike spent 10 years at Trevena Inc., most recently as Vice President of Scientific Operations, Regulatory and Alliance Management, developing novel drugs targeting G protein-coupled receptors for the treatment of cardiovascular and CNS diseases. Prior to joining Trevena, Mike served as Director of Nonclinical Pharmacology and Toxicology at Synergy Pharmaceuticals, where he worked on the development of novel small molecules/peptides for the treatment of gastrointestinal diseases. Prior to that role, Mike held roles of increasing responsibility within Nonclinical Development and Safety at Neuron Therapeutics, Palatin Technologies and Promedior, developing drugs in multiple therapeutic areas ranging from fibrotic disease to CNS conditions. Mike received his M.S. degree in Molecular Biology from Drexel University.
Elizabeth leads the biology team at Quanta Therapeutics. Prior to Quanta, Elizabeth worked at Biodesy where she developed conformation-based assays (SHG) using second-harmonic generation on a variety of protein targets. Elizabeth has deep experience in small molecule screening and cancer biology. She completed postdoctoral training at UCSF with Frank McCormick, where she designed and carried out a number of RAS-targeted small molecule campaigns using emergent technologies including SHG. Elizabeth has a Ph.D. in biochemistry and molecular biology from the University of British Columbia and a Bachelor of Science Honors degree in biochemistry from McGill University.
Dave Rominger, Senior Director of Nonclinical Drug Development, has over 35 years of experience in drug discovery and development at both large pharmaceutical and small biotech companies with a focus on leading IND-enabling activities. Prior to joining Quanta, he was Director of Drug Metabolism and Analytical Sciences at Prelude Therapeutics, where he member of the discovery and non-clinical development teams responsible for leading strategy and conduct of DMPK, safety pharmacology and general toxicology studies. Prior to Prelude, Dave was Associate Director of Non-clinical Development at Trevena, where he was responsible for support of G protein-biased ligand drug discovery screening, assay development and leading external non-clinical development activities, including DMPK and safety pharmacology, and he was an Investigator in the Enzymology and Mechanistic Pharmacology Department, Oncology Center of Excellence in Drug Discovery at GlaxoSmithKline. Before joining GSK, Dave was a Senior Research Scientist in the CNS Diseases department for 17 years at DuPont, where he supported drug discovery programs related to several therapeutic areas in neuroscience. Dave received his B.S. in Biology from The Catholic University of America.
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